-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Background: Responses to changes in blood glucose are influenced by the confluence of different mechanisms that maintain homeostasis of blood glucose levels in healthy individuals
Inefficient glycemic homeostasis underlies a clinically silent metabolic disorder state that represents an early stage of development of type 2 diabetes
The genetic basis of susceptibility to type 2 diabetes has been intensively studied, and genome-wide association studies using a multicenter approach have identified more than 120 distinct genetic loci as risk factors for type 2 diabetes
Methods: We analyzed the genetic control of the DPP4 gene in response to insulin release following OGTT, in a predominantly European cohort of the Portuguese population, including normoglycemic and prediabetic individuals, and in a mouse model of DPP4 deficiency and a high-energy diet.
RESULTS: In normoglycemic individuals, DPP4 single nucleotide variants controlled glycemic excursions (rs4664446, p=1.
Table 1 Glucose metabolism variables in NGT and prediabetic participants in the prediabetic population
Table 1 Glucose metabolism variables in NGT and prediabetic participants in the prediabetic populationFigure 1.
Figure 1.
Table 2 Peak correlation of DPP4 with blood glucose and C-peptide levels at 30 minutes and 120 minutes after OGTT in NGT patients
Table 2 Peak correlation of DPP4 with blood glucose and C-peptide levels at 30 minutes and 120 minutes after OGTT in NGT patientsFigure 2 DPP4 is associated with experimental post-OGTT responses in mice under normal diet or HCD
Figure 2 DPP4 is associated with experimental post-OGTT responses in mice under normal diet or HCD
These results suggest that the DPP4 gene is an important determinant of post-OGTT levels by a mechanism that is abolished in prediabetes
Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretionLeave
a comment