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    Home > Active Ingredient News > Endocrine System > Diabetologia: genetic control of postprandial blood glucose and insulin secretion by blunting DPP4 in prediabetes

    Diabetologia: genetic control of postprandial blood glucose and insulin secretion by blunting DPP4 in prediabetes

    • Last Update: 2022-04-19
    • Source: Internet
    • Author: User
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    Background: Responses to changes in blood glucose are influenced by the confluence of different mechanisms that maintain homeostasis of blood glucose levels in healthy individuals


    Inefficient glycemic homeostasis underlies a clinically silent metabolic disorder state that represents an early stage of development of type 2 diabetes


    The genetic basis of susceptibility to type 2 diabetes has been intensively studied, and genome-wide association studies using a multicenter approach have identified more than 120 distinct genetic loci as risk factors for type 2 diabetes


    Methods: We analyzed the genetic control of the DPP4 gene in response to insulin release following OGTT, in a predominantly European cohort of the Portuguese population, including normoglycemic and prediabetic individuals, and in a mouse model of DPP4 deficiency and a high-energy diet.


    RESULTS: In normoglycemic individuals, DPP4 single nucleotide variants controlled glycemic excursions (rs4664446, p=1.


    Table 1 Glucose metabolism variables in NGT and prediabetic participants in the prediabetic population

    Table 1 Glucose metabolism variables in NGT and prediabetic participants in the prediabetic population

    Figure 1.


    Figure 1.


    Table 2 Peak correlation of DPP4 with blood glucose and C-peptide levels at 30 minutes and 120 minutes after OGTT in NGT patients

    Table 2 Peak correlation of DPP4 with blood glucose and C-peptide levels at 30 minutes and 120 minutes after OGTT in NGT patients

    Figure 2 DPP4 is associated with experimental post-OGTT responses in mice under normal diet or HCD


    Figure 2 DPP4 is associated with experimental post-OGTT responses in mice under normal diet or HCD


    These results suggest that the DPP4 gene is an important determinant of post-OGTT levels by a mechanism that is abolished in prediabetes


    Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretionLeave

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