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At the annual meeting of the European Association for the Study of Diabetes (EASD) held online this year (September 27-October 1), a new study is being published, recommending that patients with type 2 diabetes consume low-calorie food 15 minutes before meals.
Whey protein microgel can reduce the spike in blood sugar after a meal and improve the body's insulin response (clearing glucose in the blood)
.
Whey is one of the main proteins found in dairy products.
It is well known that whey increases the production of glucagon-like peptides (GLP-1) in the intestines.
This hormone triggers the production of insulin, which in turn reduces postprandial blood sugar.
Elevated
.
However, its regular use as a natural dietary supplement is limited because it requires a relatively high protein dose and high calorie content, and it needs to be taken 30-60 minutes before meals
Now, researchers have developed a new "gel" technology that allows the body to obtain whey protein faster, so you can take a low dose of whey protein (10 g, 40 kcal) 15 minutes before meals
.
The study included 26 patients with type 2 diabetes (14 women, average age 62), some of whom were taking metformin (an oral diabetes medication)
Blood samples were collected 15 minutes before eating whey protein or placebo and more than 4 hours after eating
.
One week after the initial study visit, participants were assigned to repeat the trial with replacement therapy (whey protein microgel injection or placebo)
.
The crossover design of the trial also means that despite the small number of participants, the study is statistically well motivated
The researchers found that the blood sugar level of the whey protein group was reduced by 22% compared with the placebo group at 2 hours after the meal, and the blood sugar level was consistently lowered 2-4 hours after the meal
.
In addition, in the whey protein group, both insulin response and GLP-1 response were significantly increased (61% at 1 hour and 66% at 2 hours, respectively)
However, the whey protein injection group and the placebo group had similar responses to peptide YY (PYY) and glucose-dependent insulinotropic polypeptide (GIP) that also stimulated insulin production
.
There were no adverse events in this study
"Our promising results support the use of this pre-meal soluble whey protein microgel as an additional option to improve early insulin response and GLP-1 response, which is usually lacking in type 2 diabetes, especially in more In the late stage, it helps to control the spike in blood sugar, which is related to cardiovascular disease, cancer, kidney failure and eye damage and other health problems
.
" said Dr.
The author points out some limitations, including that this is a small, experimental study conducted in a single center in the United States, and most of the study participants are white, so the results cannot be generalized to all races in other countries
Magazine
Diabetologia
