Diabetologia: Type 1 Diabetes in Children: A Nationwide Correlation Study.

Type 1 diabetes is an autoimmune disease that affects around 400,000 people in the UK.
it is likely that environmental factors trigger the disease process of genetically susceptible individuals.
We used an ambisy, eco-environment-wide correlation study (EnWAS) approach to assess the association between environmental factors and the incidence of type 1 diabetes in children in the UK to validate assumptions about environmental triggers.
We conducted an analysis at the local authority area (LAD) level using a type 1 diabetes dataset based on national hospital event statistics, which included 13,948 people aged 0-9 between April 2000 and March 2011.
we constructed an assessment of the LAD analysis level based on a range of potential demographic and environmental risk factors, including meteorological, land use and environmental pollution variables.
the relationship between the incidence and risk factors of type 1 diabetes through Poisson regression, disease location and ecological regression.
study showed that the number of LAD cases ranged from 1 to 236 (median 33, 24-46 between quarters).
incidence of type 1 diabetes was 21.2 (95% CI 20.9, 21.6) / 100,000.
EnWAS and disease maps show that 15 out of 53 population and environmental risk factors are significantly associated with the incidence of diabetes.
these pollutants include air pollutants (particles, nitrogen dioxide, nitrogen oxides, carbon monoxide;
map shows type 1... MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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