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Diabetologia: Using human genetic data to study the effect of glucose-dependent insulin-promoting polypeptide signals on cardiometabolism

 Last Update: 2021-12-03
 Source: Internet
 Author: User

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Glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory polypeptide, GIP) is an insulin polypeptide that stimulates insulin secretion after oral nutrient intake

RESULTS: There were five results in the evidence that GIP and GIPR genes co-localize with the genetic associations of type 2 diabetes susceptibility

Table Genome-wide association studies used to obtain summary statistics

Figure (A) OR and (be) effect size estimation for heart failure risk (MRβ coefficient, body mass index [b], C-reactive protein [c], high-density lipoprotein cholesterol [d] and triacylglycerol levels [e], All in SD) and its 95% cis-acting halved the risk of type 2 diabetes by genetic agents

This study provides genetic evidence that the beneficial effects of sustained GIP signaling on cardiometabolic health are greater than expected to improve blood glucose control alone

Karhunen V, Daghlas I, Zuber V,et al.

Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling.

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