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    Home > Active Ingredient News > Endocrine System > Diabetologia: Young-onset diabetes in Asian Indians is associated with measured and genetically determined decreased beta cell function

    Diabetologia: Young-onset diabetes in Asian Indians is associated with measured and genetically determined decreased beta cell function

    • Last Update: 2022-04-20
    • Source: Internet
    • Author: User
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    Background: The prevalence of diabetes is increasing, which is a major burden of morbidity in South Asia
    .


    The International Diabetes Federation predicts that by 2045, 151.


    The prevalence of diabetes is rising, which is a major burden of morbidity in South Asia


    They found that Asian-Indian men who developed diabetes during a 20-year follow-up period had lower BMI, higher waist-to-hip ratio, higher trunk skinfold thickness, higher insulin resistance, and beta-cell function compared with white Europeans Enhanced (compensatory), but no difference in lipids


    Although it has been established that type 2 diabetes in Asian Indians is characterized by an earlier age of onset and a relatively low or lower BMI, no large-scale study has been conducted to comprehensively describe the prevalence of type 2 diabetes in young, slim Asian Indians Metabolic phenotype and genetic risk


    Methods: Using two Asian Indian cohorts, the ICMR-INDIAB cohort (Indian Council of Medical Research - Indian Diabetes Study) and the DMDSC cohort (Dr Mohan's Diabetes Specialist Centre), and a white European, ESDC (East Scotland Diabetes Cohort) )
    .


    Using a cross-sectional design, we examined the relative prevalence of healthy, overweight, and obese young adults with diabetes, classified according to their BMI


    RESULTS: The prevalence of young-onset diabetes with normal BMI was 9.
    3% among white Europeans and 24%-39% among Asian Indians
    .


    Among young-onset Asian Indians, lean compared with obese had 492 pmoL/ml lower stimulated C-peptide after adjustment for family history of type 2 diabetes, sex, insulin sensitivity, and high-density lipoprotein-cholesterol (IQR353-616 , p<0.


    Figure 1.
    Bar graph of the proportion of early-onset diabetes in each BMI category among Asian Indians (blue, ICMR-INDIAB cohort; red, DMDSC cohort) and European whites (grey, ESDC cohort)
    .


    Asian Indians have a normal BMI <23 kg/m2, and overweight is defined as a BMI of 23-25 ​​kg/m2 and a body mass index >25 kg/m2


    Figure 1.


    Table 1 Comparison of characteristics of young and older Asian-Indians diagnosed as

    Table 1 Comparison of characteristics of young and older Asian-Indians diagnosed as

    Figure 2 is a block diagram showing lower fasting C-peptide levels (A) and stimulated C-peptide levels (B) by BMI
    .


    The data shown are from a DMDSC cohort of Asian Indians with type 2 diabetes


    Figure 2 is a block diagram showing lower fasting C-peptide levels (A) and stimulated C-peptide levels (B) by BMI


    The prevalence of lean body mass index in young-onset diabetes was more than twice as high among Asian Indians as among white Europeans


    Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function.
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