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Background: The prevalence of diabetes is increasing, which is a major burden of morbidity in South Asia
.
The International Diabetes Federation predicts that by 2045, 151.
The prevalence of diabetes is rising, which is a major burden of morbidity in South Asia
They found that Asian-Indian men who developed diabetes during a 20-year follow-up period had lower BMI, higher waist-to-hip ratio, higher trunk skinfold thickness, higher insulin resistance, and beta-cell function compared with white Europeans Enhanced (compensatory), but no difference in lipids
Although it has been established that type 2 diabetes in Asian Indians is characterized by an earlier age of onset and a relatively low or lower BMI, no large-scale study has been conducted to comprehensively describe the prevalence of type 2 diabetes in young, slim Asian Indians Metabolic phenotype and genetic risk
Methods: Using two Asian Indian cohorts, the ICMR-INDIAB cohort (Indian Council of Medical Research - Indian Diabetes Study) and the DMDSC cohort (Dr Mohan's Diabetes Specialist Centre), and a white European, ESDC (East Scotland Diabetes Cohort) )
.
Using a cross-sectional design, we examined the relative prevalence of healthy, overweight, and obese young adults with diabetes, classified according to their BMI
RESULTS: The prevalence of young-onset diabetes with normal BMI was 9.
3% among white Europeans and 24%-39% among Asian Indians
.
Among young-onset Asian Indians, lean compared with obese had 492 pmoL/ml lower stimulated C-peptide after adjustment for family history of type 2 diabetes, sex, insulin sensitivity, and high-density lipoprotein-cholesterol (IQR353-616 , p<0.
Figure 1.
Bar graph of the proportion of early-onset diabetes in each BMI category among Asian Indians (blue, ICMR-INDIAB cohort; red, DMDSC cohort) and European whites (grey, ESDC cohort)
.
Asian Indians have a normal BMI <23 kg/m2, and overweight is defined as a BMI of 23-25 kg/m2 and a body mass index >25 kg/m2
Figure 1.
Table 1 Comparison of characteristics of young and older Asian-Indians diagnosed as
Table 1 Comparison of characteristics of young and older Asian-Indians diagnosed asFigure 2 is a block diagram showing lower fasting C-peptide levels (A) and stimulated C-peptide levels (B) by BMI
.
The data shown are from a DMDSC cohort of Asian Indians with type 2 diabetes
Figure 2 is a block diagram showing lower fasting C-peptide levels (A) and stimulated C-peptide levels (B) by BMI
The prevalence of lean body mass index in young-onset diabetes was more than twice as high among Asian Indians as among white Europeans
Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function.
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