Diagn Pathol: The Treg/Th17 ratio can be used as a potential marker for predicting insanity cirrhosis.

Recent studies have shown that T-cell-mediated cellular immune mechanisms play an important role in the progression of hepatitis B into cirrhosis, but their basic mechanisms are still unclear.
study aims to determine the relationship between Treg/Th17 and hepatitis B-related cirrhosis, the findings have been published online in Diagn Pathol.
used a flow cytometer to determine the frequency of Treg and Th17 cells in the outer blood of all participants, including 93 patients with hepatitis B-related cirrhosis and 40 healthy people.
study the prognostic significance of Treg/Th17 ratio to non-compensation cirrhosis by applying Cox regression model and subject working characteristic curve.
results showed that patients with hepatitis B-related cirrhosis had a Treg/Th17 imbalance, with fewer Treg cells in their outer blood, an increase in Th17 cells, and a decrease in the Treg/Th17 ratio.
treg and Th17 cells were negatively related.
TheTreg/Th17 imbalance was closely related to the clinical stage of hepatitis B-related cirrhosis.
the Cox regression model, viral load, Treg frequency, and Treg/Th17 ratio are independent factors in predicting insanity cirrhosis.
ROC analysis showed that the Treg/Th17 ratio was the best marker for predicting non-compensation cirrhosis.
, the results show that the Treg/Th17 imbalance is involved in the pathogenesis of hepatitis B-related cirrhosis, and the Treg/Th17 ratio can be used as a potential marker for predicting unresoconsced cirrhosis.
.