Dialysis treatment takes an important step towards precision medicine

Science and Technology Daily, Berlin, November 2 (Reporter Li Shan) Recently, an international research team led by scientists from the University of Zurich found that a common gene mutation of aquaporin-1 (AQP1) reduces the number of water channels in the cell membrane, and thus Increase the risk of death in patients receiving peritoneal dialysis due to renal failure

As many as 10% of people worldwide are affected by chronic kidney disease

Recently, an international team of researchers from 6 countries led by Professor Olivier DeVester of the University of Zurich’s Institute of Physiology found that a common variant of the AQP1 gene has a significant impact on the effectiveness of peritoneal dialysis and the survival of patients.

To test the effect of genetic variants in AQP1 on the results of ultrafiltration and dialysis, the researchers examined 1851 patients of different ethnicities over a few years

For patients undergoing peritoneal dialysis and this variant of the AQP1 gene, the treatment will not completely remove the excess water because there are fewer water channels in the cells