Early life (embryo, newborn, early years, etc.
) is a critical period for brain development, and neglect in early life can have irreversible effects
on nervous system and emotional development.
In recent years, it has been reported that brain regions including the prefrontal cortex, orbitofrontal lobe, and amygdala are involved in the neural processes
of this emotional behavior.
Preliminary work of Professor Qin Chuan's team at Peking Union Medical College-Institute of Medical Laboratory Animals, Chinese Academy of Medical Sciences (Sun X et al.
2020) has confirmed that glutamatergic neurons in the prefrontal cortex are involved in regulating behaviors such as anxiety in model rats with neglect of early life, and intrinsic excitatory changes in neurons in the prefrontal cortex may be the basis for behavioral phenotypes and sex differences in
This article further explores the different neuroexcitatory changes of glutamatergic neurons and GABAergic neurons in the prefrontal cortex of rats between male and female rats, and explores the corresponding neural mechanisms
for the behavioral symptoms of disease model animals.
In this study, the maternal separation with early weaning (MSEW) model of rat mother separation (MSEW) was established as a disease model neglected in early life, and glutamatergic neurons and GABAergic neurons in the prefrontal cortex of rats were recorded by whole-cell brain patch patch-clamp, and the changes in the intrinsic excitability of
each group were detected.
The results showed that prefrontal glutamatergic neurons and GABAergic neurons showed neurophysiological changes with different characteristics using neuronal action potential and amplitude, threshold and number as detection indicators: the excitability of glutamatergic neurons increased significantly in the male model group, which was more likely to excite the action potential, and there was no obvious difference in
the female model group.
Different from glutamatergic neurons, the excitability of GABAergic neurons is manifested by the increase of the absolute value of a single action potential threshold in the male and female model groups, which is not easy to excite the action potential
Figure 1: Intrinsic excitability analysis of glutamatergic neurons and GABAergic neurons in the prefrontal cortex of rats
In summary, the prefrontal cortex of the early weaning model of rat mother-child isolation showed neuron-specific excitatory changes, and at the same time there were male and female differences, which further caused the excitability-inhibition balance of the prefrontal cortex to change, which provided a neurological basis
for the emotional behavioral phenotype of rat mother-child isolation early weaning.
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