On October 2, Immunity Magazine published online the research paper "B cells are the dominant the san antigen-on-the-table cells that the ada cd4-T cells with a virus-derived nanoparticle antigen" by the Hou Baidong Research Group of the Institute of Biophysics of the Chinese Academy of Sciences in collaboration with the Tang Hong Group of the Shanghai Pasteur Institute of the Chinese Academy of Sciences.
work found a new mechanism for nanoparticle antigen activation of CD4 T cells.
dendritic cells have long been thought to be the only antigen-raised cells in the body that can present antigens to the initial state CD4 T cells.
B cells and macrophages can also raise antigens, but they can only activate the effect T cells or memory T cells.
increasing evidence suggests that dendritic cells are not required to activate CD4 T cells in the initial state under certain conditions, and what antigen-raised cells in the body are able to activate the initial state CD4 T cells? Using a laboratory-specific Q beta virus-like particle system, the researchers studied the activation process of specific CD4 T cells targeting this particulate antigen during viral-sample dissonization.
they found that antigen-specific B cells were able to ingest antigens quickly and then directly activate the initial state CD4 T cells, a process that did not depend on DCs cells, and they found that TLR signals expressed by B cells play edimen and differentiation of CD4 T cells.
this study proves that antigen-specific B cells can activate the initial state CD4 T cells, changing the original idea that only DCs in the body can activate the initial state CD4 T cells, and have a new understanding of the CD4 T cell response to the antiviral process.
the findings will help people understand the mechanisms by which B cells play a role in anti-infective and autoimmune.
new targets and theoretical guidance for the future development of new vaccines and immunotherapy methods.
the work was completed by Hou Baidong task force in cooperation with Tang Hong's team.
Institute of Biophysics researcher Hou Baidong, associate researcher Hua Zhaolin and Shanghai Pasteur Institute researcher Tang Hong as co-authors of the paper, Hou Baidong group assistant researcher Hong Sheng is the first author of the paper.
work obtained the cooperation and support of Zhu Bing Task Force of the Institute of Biophysics, Zhang Fuping Ofdusco Of the Institute of Microbiology of the Chinese Academy of Sciences, zhou Xuyu Task Force, and Ge Qing Group of Peking University School of Medicine.
the research is supported by the NSFC and the Chinese Academy of Sciences.
Source: Institute of Biophysics.