Dig Dis Sci: Aspartate aminotransferase to platelet ratio index predicts the risk of postoperative liver failure in patients with colorectal cancer liver metastases

Colorectal cancer (CRC) is the third most common cancer worldwide and the third most common cause of cancer-related death in the United States, with liver metastases occurring in approximately 50% of patients diagnosed with CRC throughout the natural history of the disease, and Liver metastases have occurred in 14-18% of newly diagnosed cases
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After resection of the primary tumor and all metastases, the 5-year survival rate can reach 50%, and the 10-year survival rate can reach 38%

Colorectal cancer (CRC) is the third most common cancer worldwide and the third most common cause of cancer-related death in the United States, with liver metastases occurring in approximately 50% of patients diagnosed with CRC throughout the natural history of the disease, and Liver metastases have occurred in 14-18% of newly diagnosed cases

 

A total of 2374 patients were identified and included in the analysis for this study
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Compared with the Model for End-Stage Liver Disease (MELD) score, APRI was shown to be a better predictor of postoperative liver failure, with a statistically significant larger area under the curve

statistics

Figure: Predictive power of the aspartate aminotransferase to platelet ratio index

 

From these studies, the authors demonstrated that in patients receiving preoperative chemotherapy, APRI was independently associated with liver failure after hepatectomy and perioperative bleeding requiring blood transfusion
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The agreement index showed a significant contribution of APRI as a predictor of postoperative liver failure

From these studies, the authors demonstrated that in patients receiving preoperative chemotherapy, APRI was independently associated with liver failure after hepatectomy and perioperative bleeding requiring blood transfusion

Yazan Ashouri.

Aspartate Aminotransferase-to-Platelet Ratio Index Predicts Liver Failure After Resection of Colorectal Liver Metastases.
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