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The clinical course of cirrhosis is mainly determined by progressive exacerbation of portal hypertension, hyperdynamic circulation, bacterial translocation, and activation of systemic inflammation
.
Clinical decompensation (CD) is associated with the progression of these mechanisms and can be identified by hemodynamic or clinical features
The clinical course of cirrhosis is mainly determined by progressive exacerbation of portal hypertension, hyperdynamic circulation, bacterial translocation, and activation of systemic inflammation
We included patients with advanced chronic liver disease (aCLD) [histological cirrhosis (n = 196) or liver stiffness measurement (LSM) > 15 kPa (n = 65)] and HVPG 6-10 mmHg
.
The primary objective was to study changes in their natural history and differences in CD patterns
Of the 261 patients with HVPG 6-10 mmHg, 129 (49.
4%) had CD at presentation; the most common CD manifestations were ascites (n = 77) and jaundice (n = 65)
.
Baseline HVPG ≥ 8 mmHg was independently associated with greater risk of CD [HR: 1.
Figure: ROC curve of hepatic venous pressure gradient
The results of this study confirmed that nearly half of patients with HVPG 6-10 mmHg had CD
.
Interventions to reduce portal pressure in patients with HVPG ≥8 mmHg may improve long-term outcomes
The results of this study confirmed that nearly half of patients with HVPG 6-10 mmHg had CD
Ankur Jindal.
Clinical Outcomes in Patients with Advanced Chronic Liver Disease and Hepatic Venous Pressure Gradient ≤ 10 mm Hg.
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