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Pancreatic necrosis due to infection is one of the most serious complications of acute pancreatitis (AP).
the emergence of secondary infections with acute pancreatitis doubles the risk of late-stage death from necrotitis.
compared to other inflammatory indicators, the neutral granulocyte-lymphocyte ratio (NLR) is considered to be one of the most valuable indicators for predicting mortality in AP patients, and phagocytosphage cells are the primary immune cells that play a major role in SAP incidence.
The expression of CD64 and HLA-DR expression in monocytes and neutrocytes is recommended as SAP markers for early prediction of local and systemic complications, so this study aims to explore the relationship between the number and function of phagocytosis and the risk of subsequent seizures of infection complications in AP patients.
researchers conducted a retrospective analysis of 97 AP patients.
the metabolic status is analyzed based on the phagocytosis activity and the production of reactive oxygen (ROS) of exocytes, which are measured by a fluid cytometer upon hospitalization.
clinical observation endpoint with AP infection complications as the main observation index.
results showed that the baseline value and reactive reserve of monocytes and neutral granulocyte phagocytosis activity in AP patients with sepsis complications decreased significantly upon hospitalization, while the production of monocyte ROS increased significantly compared to groups without infection processes.
the ROC curve area of the neutral granulocytes and monocytes devouring reaction activity reserves obtained by the united States were 0.95 (P-lt;0.0001) and 0.84 (P-lt;0.0001), respectively, and were clearly a risk factor for infection complications.
, the researchers say quantitative analysis and functional indicator testing of phagocytosis early in the hospitalization of AP patients can be used to diagnose SAP patients and the occurrence of infectious complications.
