Dig Dis Sci: Methyl sulfonate is ineffective against the prevention of retrograde pancreatic bile tube oc inflammatory pancreatitis after endoscopy

Endoscopic retrograde pancreatic bile tube anthotomy (ERCP) is an important endoscopic technique currently used worldwide to treat pancreatic bile tube disease.
ERCP mainly include pancreatitis, bleeding, bile tubeitis, gallbladderitis and perforation.
these complications, postoperative pancreatitis (PEP) is the most common, with an incidence of about 2-15%.
protease inhibitors have the effect of preventing PEP by inhibiting the conversion of trypsin to trypsin in pancreatic bubble cells and preventing subsequent inflammation.
protease inhibitor among them - nimoxythamethane sulfonate (6--based-2-terpene-to-phenylphenylate dimethane sulfonate; NM) efficacy is currently more controversial.
, a multi-center randomized controlled trial of NM's preventive effects in PEP is needed.
the multi-center prospective study, researchers included 800 patients aged 20 who planned to perform ERCP between December 2012 ≥ March 2019.
observations were the difference between the occurrence and severity of PEP in patients who did not receive NM (non-NM) and those who received NM treatment (NM: 20 mg/day).
observations included risk factors for PEP and adverse events associated with NM.
441 out of 800 patients were included in the study (non-NM:n=149; NM：n = 292）。
patient characteristics remained relatively balanced at baseline, with no significant differences between groups.
the total PEP occurrence rate of 40/441 (9%), (non-NM:n s 15 s 10%); NM:n s 25 s 9%)).
the NM treatment group, the rate of PEP was lower in the low-risk group than in the high-risk group.
pancreatic puncture and double-wired drain technology are independent risk factors for PEP.
of adverse events such as NM-related high potassiumemia was 0.7%.
this study confirms that NM has a preventive effect on PEP, regardless of the time of dosing, but further research is needed.