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Bile acid diarrhea (BAD), also known as bile acid malabsorption (BAM), is a common cause of chronic diarrhea
.
The mechanism is that excess bile acids reach the colon and interact with GPBAR1 or TGR5, resulting in increased colonic motility and fluid secretion
Bile acid diarrhea (BAD), also known as bile acid malabsorption (BAM), is a common cause of chronic diarrhea
immunity
A total of 60 chronic diarrhea patients and 80 healthy volunteers (HV) were collected for this study
.
According to the 90th percentile level of HV serum 7a-hydroxy-4-cholesten-3-one (C4), these patients were divided into BAD group (C4≥90th) and non-bile acid diarrhea group (NBAD, C4<90th) ) )
The results of the study showed that the 90th percentile of serum C4 in the HV group was 65.
87 ng/ml
.
Serum FGF19 concentrations were significantly lower in the BAD group (median 69.
statistics
Figure: Differences in the levels of fibroblast growth factor 19 in different patients
Figure: Differences in the levels of fibroblast growth factor 19 in different patientsThis study demonstrated that serum and distal ileal expression of FGF19 was significantly reduced in BAD patients
.
Serum FGF19 <117.
This study demonstrated that serum and distal ileal expression of FGF19 was significantly reduced in BAD patients
Original source:
Chunxia Chang.
Chunxia Chang.
Et al.
Downregulation of Serum and Distal Ileum Fibroblast Growth Factor19 in Bile Acid Diarrhoea Patients.
Digestive Diseases and Sciences.
2022.
Downregulation of Serum and Distal Ileum Fibroblast Growth Factor19 in Bile Acid Diarrhoea Patients.
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