echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Digestive System Information > Dig Dis Sci: Serum and terminal ileal fibroblast growth factor 19 was significantly downregulated in patients with bile acid diarrhea and correlated with disease severity

    Dig Dis Sci: Serum and terminal ileal fibroblast growth factor 19 was significantly downregulated in patients with bile acid diarrhea and correlated with disease severity

    • Last Update: 2022-04-24
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Bile acid diarrhea (BAD), also known as bile acid malabsorption (BAM), is a common cause of chronic diarrhea
    .


    The mechanism is that excess bile acids reach the colon and interact with GPBAR1 or TGR5, resulting in increased colonic motility and fluid secretion


    Bile acid diarrhea (BAD), also known as bile acid malabsorption (BAM), is a common cause of chronic diarrhea


    immunity

    A total of 60 chronic diarrhea patients and 80 healthy volunteers (HV) were collected for this study
    .


    According to the 90th percentile level of HV serum 7a-hydroxy-4-cholesten-3-one (C4), these patients were divided into BAD group (C4≥90th) and non-bile acid diarrhea group (NBAD, C4<90th) ) )


    The results of the study showed that the 90th percentile of serum C4 in the HV group was 65.
    87 ng/ml
    .


    Serum FGF19 concentrations were significantly lower in the BAD group (median 69.


    statistics

    Figure: Differences in the levels of fibroblast growth factor 19 in different patients

    Figure: Differences in the levels of fibroblast growth factor 19 in different patients

    This study demonstrated that serum and distal ileal expression of FGF19 was significantly reduced in BAD patients
    .


    Serum FGF19 <117.


    This study demonstrated that serum and distal ileal expression of FGF19 was significantly reduced in BAD patients


    Original source:

    Chunxia Chang.


    Chunxia Chang.
    Et al.
    Downregulation of Serum and Distal Ileum Fibroblast Growth Factor19 in Bile Acid Diarrhoea Patients.
    Digestive Diseases and Sciences.
    2022.
    Downregulation of Serum and Distal Ileum Fibroblast Growth Factor19 in Bile Acid Diarrhoea Patients.
    Leave a comment here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.