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Crohn's disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD), an idynogenic chronic relapse that has become a global public health challenge as IBD's prevalence continues to rise in Western and Eastern countries.
esophageal and IBD causes are complex, and patients are at risk of several micronutrient deficiencies, and there have been reports of an increased risk of vitamin D deficiency in IBD patients.
it is well known that vitamin D deficiency can lead to metabolic bone diseases such as bone reduction and osteoporosis.
addition, vitamin d is an important cause of involvement in immunomodulation (congenital and adaptive immunity) and affecting gut microorganisms.
study was conducted to analyze whether the status of serum 25-hydroxyvitamin D3 (OH)-D3) was associated with IBD clinical characteristics and affected surgical risk in IBD patients.
researchers collected clinical data from all patients who had at least one 25-(OH)-D3 measurement.
then, the association between all clinical factors and 25-(OH)-D3 states was analyzed.
25-(OH)-D3 levels are defined as relative defects, defects and serious defects, respectively, at the levels of slt;30, slt;20 and slt;10 ng/mL.
study included clinical data on 711 patients with Crohn's disease (CD) and 764 cases of ulcerative colitis (UC) who had not underwent surgery before measuring 25-(OH)-D3.
in CD and UC patients, the reduced 25-(OH)-D3 was associated with higher disease activity scores and CRP levels (p .lt;0.001).
severe 25-(OH)-D3 deficiency is associated with severe disease behavior with colorectal disease and CD (p .lt;0.05) and with the degree of disease in UC (p-lt;0.001).
in the multivarivariable analysis, the severe lack of 25-(OH)-D3 in CDs (HR 1.93, 95% CI (1.3) - 2.70) and UC (HR 2.77, 95% CI (1.14-6.74)) was an independent risk factor for surgery.
study confirms that a severe 25-(OH)-D3 deficiency may be a sign of IBD's more aggressive clinical progress.
