Dig Dis Sci: Treatment with prophylactin prophylactin after colon surgery is prone to liver damage.

Colon cancer patients are prone to deep vein thrombosis after surgery, in order to reduce the occurrence of this complication, the guidelines recommend that colon cancer patients should routinely use anticoagulant treatment.
Low Molecular Weight Heparin (LMWH) - Inoheparin, a low molecular weight heparin, has been used to prevent thrombosis events during major surgery without increasing bleeding rates.
But there have also been studies that have reported that LMWH and other anticoagulants can induce elevation of transaminase and cause an increase in drug-induced liver damage (DILI), and this study aims to clarify the relationship between preventive enoheparin and liver damage after colorectal surgery.
researchers reviewed 732 Japanese patients with routine colorectomy and compared their clinical pathological background, surgical details, postoperative complications (including liver injury) and liver injury types based on the preventive use of inoparin.
a single-factor and multi-factor analysis to determine the risk factors for postoperative liver damage.
results showed that the liver injury rate was 8.9% in patients treated with prophylactin and 1.4% in patients who did not receive inoparin after colorectal surgery .
median onset of liver damage in patients treated with inoparin was 7 days, and most patients showed liver cell damage.
multivariative analysis, inoparin is one of the independent risk factors for postoperative liver damage (OR:7.63, p.lt;0.0001).
, the study's final authors say, preventive use of inoparin in patients undergoing colorectal surgery can significantly increase the incidence of postoperative liver damage.
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