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Eosinophilitis (EoE) is an antigen- or immune-driven disease characterized by esophal dysfunction and can be found in every high field of view of the esophedritis≥
The current mainstream therapeutic drug is proton pump inhibitors (PPI), but recent studies have explored the more complex relationship between PPI and EoE, so this study aims to determine clinical predictive indicators of response to EoE first-line therapies to guide medicine.
reviewed clinical data from patients diagnosed with EoE between 2011 and 2018.
clinical and diagnostic variables of PPI responders and PPI non-reactive people, including demographics, endoscopy and esopopian esopdoal ography results.
all patients were subjected to a standard PPI test twice a day for 8 weeks, and PPI reactive at the time of gastroenteroscopy (EGD) was defined as the number of biopsies and 15 eos/ hpf eos/hpf eosinophils.
single- and multi-variable analysis to identify non-response risk factors and create ROC curves to identify critical values.
the study identified a total of 223 EoE patients (135 men with a medium age of 39 (29-51 years), of whom 71% showed no PPI response (PPI-NR).
in the multivarivarial model, the age increased by 10 years (OR 0.71; P - 0.007), BMI (OR 0.94) for each reduction of 1 kg /m2; P - 0.03), the count of exostocyphils per 100 mm 3 increase (OR 1.37; P s 0.003) are independent risk factors.
-splitter maximizes sensitivity and specificity, determining age ≤36 years old, BMI≤25.2 kg/m2, and surrounding eos-gt; 460/mm 3 as the predicted threshold for PPI-NR.
the probability of PPI-NR occurring with 1 risk factor was 72.4-84.5%, the probability of having 2 risk factors was 87.9-93.8%, and the probability of having all 3 risk factors was 97.2%.
concluded: Young people, reduced BMI, elevated count of exosome acidophils, and the possible ability to pass endoscopy are all predictive indicators of the lack of response to PPI in EoE patients.
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