Inflammatory bowel disease (IBD), which is dominated by ulcerative colitis (UC) and Crohn's disease (CD), is considered a chronic nonse specific inflammation of the gastrointestinal tract.
can lead to poor nutrient absorption and complications such as bone loss and osteoporosis.
Many reports indicate that Osteoporosis and Osteoporosis are more prevalent in patients with IBD than in the general population, and that a dual-energy X-ray Bone Density Meter (DXA) can estimate bone density (BMD), which plays an integral role in determining bone strength.
Many researchers believe that the clinical risk factors for low BMD are a history of small intestine excision, low body mass index (BMI), the use of corticosteroid hormones, malnutrition (including calcium and vitamin D deficiency), the course of IBD, and smoking.
pathogenesis of low BMD in IBD patients is multi-factor and has not been fully revealed.
, this study aims to explore the prevalence and risk factors of low BMD among young Korean patients newly diagnosed with IBD.
researchers recruited 132 patients under the age of 50 who were newly diagnosed with IBD from six third-level referral centers in South Korea between November 2014 and April 2017.
BMD is measured by dual-energy X-ray absorption and the Z score is determined.
low BMD is defined as a Z-≤ of -1.0.
then perform a statistical analysis on all patients.
of the 68 patients with ulcerative colitis (UC), 22 (32.4%) were at lower levels of BMD.
, 24 (37.5%) of the 64 crohn's disease (CD) patients had lower BMD. the results of the
multiple regression analysis determined that the risk factors for low BMD in UC patients were high levels of alkaline phosphatase (ALP) (≥140 U / L) (P -0.010) and underweight (body mass index ≤18.5 kg/m2).
about one-third of Asian patients diagnosed with IBD have low levels of BMD.
clinical factors associated with low BMD were high ALP levels in UC patients and underweight in CD patients.
therefore, the measurement of BMD in young patients should be considered when diagnosing IBD.