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Dig Liver Dis: Serum bile acid and glycol deoxycholic acid levels in patients with cystic fibrosis can be used as biomarkers of liver disease

 Last Update: 2022-01-07
 Source: Internet
 Author: User

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It is well known that in patients with cystic fibrosis (CF), mutations in the transmembrane conductance regulator of CFTR (CFtr) can significantly reduce the flow of chloride ions in the cells

A total of 75 CF patients were included in this study: 25 were diagnosed with liver cirrhosis (11 women, 14 men, aged 9 to 33 years), and 25 had other non-cirrhotic liver diseases (12 women, 13 men) , 16 to 44 years old) and 25 without liver disease (12 females, 13 males, 17 to 36 years old)

The results of the study showed that, except for Glycyrrhiza deoxycholic acid (GDCA), bile acid levels in CF patients were higher than those in healthy controls

This study confirms that the specific bile acid profile in CF patients can be used to identify liver diseases

Sławomira Drzymała-Czy.

Serum bile acids in cystic fibrosis patients – glycodeoxycholic acid as a potential marker of liver disease.

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