The study, published in the Journal of Biological Chemistry, found that in the cell cycle, there is a link that has been sought for a long time between the mechanism of cell division and the mechanism of cell adhesion
Cell division is the proliferation mechanism that allows all living things to work and regenerate, and cell adhesion fixes them in the correct position in the biological structure
In order for cells to divide inside the human body, the cell must release its adhesion to the surrounding environment at the moment it begins to divide
This synchronization of cell adhesion and cell cycle is essential for the correct function of cells in tissues and preventing uncontrolled cell division during processes such as cancer
The researchers found that CDK1, the main regulator of the cell cycle, directly binds and modifies the core protein talin, which is essential for the cell adhesion process
This interaction represents the coupling of cell proliferation and adhesion processes
This indicates a unified mechanism through which the process of cell division and adhesion is controlled
Discovering the initial mechanism of this important process in human tissues is the first step in understanding a new branch of health issues related to the cell cycle (including cancer tumors)
Ben Goult, Ph.
in biochemistry at the University of Kent, is the lead researcher of this paper.
He said: "The potential of this discovery is huge because it provides a new understanding of how cell division works in a complex multicellular organism.
Coordinated within the scope
Cell division needs to be closely integrated with cell adhesion to allow cells to divide without destroying the integrity of tissues and organs
This research is essential for us to understand other cell diseases and the ability of cancer to spread in the human body
This research was funded by the Biotechnology and Biological Sciences Research Council, the Human Frontier Science Program and the Cancer Research UK
Gough, Matthew C.
Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P.
Muench, Jie Yan, Jonathan D.
Humphries, Claus Jørgensen, Martin J.
Humphries, Benjamin T.
Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1 .
Journal of Biological Chemistry , 2021; 297 (1): 100837 DOI: 10.