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    Home > Biochemistry News > Biotechnology News > Discovered a basic mechanism of human cell cycle

    Discovered a basic mechanism of human cell cycle

    • Last Update: 2021-07-30
    • Source: Internet
    • Author: User
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    The study, published in the Journal of Biological Chemistry, found that in the cell cycle, there is a link that has been sought for a long time between the mechanism of cell division and the mechanism of cell adhesion
    .
    Cell division is the proliferation mechanism that allows all living things to work and regenerate, and cell adhesion fixes them in the correct position in the biological structure

    .

    In order for cells to divide inside the human body, the cell must release its adhesion to the surrounding environment at the moment it begins to divide
    .
    This synchronization of cell adhesion and cell cycle is essential for the correct function of cells in tissues and preventing uncontrolled cell division during processes such as cancer

    .

    The researchers found that CDK1, the main regulator of the cell cycle, directly binds and modifies the core protein talin, which is essential for the cell adhesion process
    .
    This interaction represents the coupling of cell proliferation and adhesion processes

    .
    This indicates a unified mechanism through which the process of cell division and adhesion is controlled

    .

    Discovering the initial mechanism of this important process in human tissues is the first step in understanding a new branch of health issues related to the cell cycle (including cancer tumors)
    .

    Ben Goult, Ph.
    D.
    in biochemistry at the University of Kent, is the lead researcher of this paper.
    He said: "The potential of this discovery is huge because it provides a new understanding of how cell division works in a complex multicellular organism.
    Coordinated within the scope

    .
    Cell division needs to be closely integrated with cell adhesion to allow cells to divide without destroying the integrity of tissues and organs

    .
    This research is essential for us to understand other cell diseases and the ability of cancer to spread in the human body

    .
    "

    This research was funded by the Biotechnology and Biological Sciences Research Council, the Human Frontier Science Program and the Cancer Research UK
    .


    Rosemarie E.
    Gough, Matthew C.
    Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P.
    Muench, Jie Yan, Jonathan D.
    Humphries, Claus Jørgensen, Martin J.
    Humphries, Benjamin T.
    Goult.
    Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1 .
    Journal of Biological Chemistry , 2021; 297 (1): 100837 DOI: 10.
    1016/j.
    jbc.
    2021.
    100837



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