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The primary human hepatocytes (PHHs) model is the gold standard for evaluating hepatic metabolism and disposal of drugs, however, PHHs have limited sources, cannot proliferate in vitro, and rapidly lose their function during culture
.
These problems limit its widespread use
.
.
These problems limit its widespread use
.
In 2021, Pan Guoyu's group from Shanghai Institute of Materia Medica, Chinese Academy of Sciences published a paper entitled "Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion , and Toxicity”, reported the potential of organoids of novel proliferating hepatocyte-like cells, ProliHHs (Proliferating Human Hepatocytes), in drug metabolism, transport, and safety evaluation
.
Using the latest primary hepatocyte degeneration technology, the study uses the hepatocyte-like cell ProliHHs with a certain expansion ability generated from PHH as a substitute for primary human hepatocytes to study the prediction of hepatic clearance rate and bile duct excretion index of drugs.
and hepatotoxicity, etc.
, and compared the differences between conventional cell models and organoid models in ADMET work
.
.
Using the latest primary hepatocyte degeneration technology, the study uses the hepatocyte-like cell ProliHHs with a certain expansion ability generated from PHH as a substitute for primary human hepatocytes to study the prediction of hepatic clearance rate and bile duct excretion index of drugs.
and hepatotoxicity, etc.
, and compared the differences between conventional cell models and organoid models in ADMET work
.
In 2022, the paper was named the best academic paper of the DMD year (2021) by the ASPET annual meeting jury from hundreds of papers, and won the James R.
Gillette Award
.
The first authors of the paper are postgraduate students Qiao Shida and Dr.
Feng Sisi
.
This work is supported by the pilot project of the Chinese Academy of Sciences and the National Natural Science Foundation of China
.
Gillette Award
.
The first authors of the paper are postgraduate students Qiao Shida and Dr.
Feng Sisi
.
This work is supported by the pilot project of the Chinese Academy of Sciences and the National Natural Science Foundation of China
.
Figure 1.
(a) ProliHHs-P: 2D cultured prolifable ProliHHs; ProliHHs-M: 3D cultured ProliHHs organoids; (b) ProliHHs-M classical drug clearance study; (c) ProliHHs-M drug bile Excretion study; (d) Hepatotoxicity prediction study of ProliHHs
.
(a) ProliHHs-P: 2D cultured prolifable ProliHHs; ProliHHs-M: 3D cultured ProliHHs organoids; (b) ProliHHs-M classical drug clearance study; (c) ProliHHs-M drug bile Excretion study; (d) Hepatotoxicity prediction study of ProliHHs
.
Figure 2.
(a) James R.
Gillette Best Paper Certificate; (b) ASPET Annual Conference Report Video (screenshot)
(a) James R.
Gillette Best Paper Certificate; (b) ASPET Annual Conference Report Video (screenshot)
(Contributed by: Pan Guoyu's research group)
