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    Home > Biochemistry News > Biotechnology News > DNA markers help blood tests evaluate cancer treatment results

    DNA markers help blood tests evaluate cancer treatment results

    • Last Update: 2021-07-30
    • Source: Internet
    • Author: User
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    Cell death is a normal part of tissue regeneration.
    In the process of cell death, cfDNA is shed from the tissue

    cfDNA can be isolated from blood samples to provide a reading of the death of normal cells and cancer cells throughout the body without the need to collect invasive biopsy samples


    "Tumor tissue biopsy is an accidental or accidental process, which usually does not reflect the entire tumor or its spread very well," said Anton Wellstein, MD, a professor of oncology and pharmacology at Georgetown Lombardi University and this article.
    Corresponding author of the article

    "On the other hand, the use of blood or liquid biopsy can provide a homogeneous representation of cfDNA shed from all types of cells


    Scientists have noticed that short fragments of DNA and chemical modifications to these fragments, known as methyl groups, help tell researchers what cell type the respective DNA fragments come from, because these methylation patterns are unique to specific cell types Of
    By using cfDNA to compare damaged cells from different treatment modalities with undamaged normal cells from the same tissue, researchers can analyze valuable data about how cells in the tissue are affected by treatment and other external forces

    This knowledge may be the key to assessing whether the treatment is effective and what adverse reactions may be caused


    “Fine-tuning these applications of cfDNA analysis is challenging and requires in-depth methods, both at the genome sequencing level and computationally,” explains Megan Barefoot, a PhD/PhD in the Wellstein Laboratory at the Cancer Center Sheng is also the main author of this article
    "Methylated cfDNA opens up a new minimally invasive method to detect damaged cells in the body.
    There are often hundreds of methyl markers for each cell to mark, very special, where the cells come from, like a "barcode scanner" Checking out at a grocery store tells the store the identity of a particular product

    Combining biology and computational analysis, it is possible to decipher these methylation patterns/molecular barcodes, so researchers can trace the origin of cfDNA


    For example, the final results of these analyses can help researchers determine the tissue source of cancer, and also allow researchers to see the source of damage when comparing damaged cells with healthy cells, especially if it is due to a certain type of treatment

    "This method can be applied to any treatment that affects tissue balance by causing tissue cell damage and death, including chemotherapy, radiotherapy, and immunotherapy
    This review really helps to lay the foundation for our future research work," Wellstein concluded Tao

    "My laboratory is very actively seeking to further improve the methods and techniques of methylated cfDNA analysis

    We believe that these efforts are affordable and will soon become laboratory standards, and they should advance the understanding of many cancers.
    And treatment


    Georgetown University (Georgetown University) filed a patent application on some of the aspects mentioned in the article, and Wellstein and Barefoot are the named inventors

    This work was partially funded by the National Institutes of Health (T32 CA009686, F30 CA250307, ​​R01 CA23129 and P30 CA51008)

    Journal Reference :

    1. Megan E.
      Barefoot, Netanel Loyfer, Amber J.
      Kiliti, A.
      Patrick McDeed, Tommy Kaplan, Anton Wellstein.
      Detection of Cell Types Contributing to Cancer From Circulating, Cell-Free Methylated DNA .
      Frontiers in Genetics , 2021; 12 DOI: 10.
      3389 /fgene.

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