Do you know six classic drug recalls?

Recently, ranitidine, a widely used stomach drug, has been involved in the impurity storm The incident began in September this year when the FDA of the United States found the suspected impurity of N-nitrosodimethylamine (NDMA) in some enterprises, such as Zantac (ranitidine) So far, pharmaceutical Novartis / Sandoz and Apotex have recalled the product Ranitidine from other companies is still on drugstore shelves According to the data, ranitidine is the first blockbuster to sell more than US $1 billion, and the first drug in the history of pharmaceutical industry with cumulative sales of US $50 billion Patients always take medicine according to the prescription issued by doctors, because they believe that doctors are the most professional So when a well-known drug is recalled, it's a bolt from the blue for the public It's often heavy news that the best-selling drugs are removed from the shelves Let's take a look at the six major recalled drugs that deserve our attention You should be familiar with the Valsartan incident that almost brought Huahai to a standstill in 2018 These are exactly three kinds of drugs, but all belong to the class of angiotension II receptor antagonists (ARB), which are used to treat hypertension The cause of this is the US FDA The impurities of nitrosamines in valsartan APIs produced by Huahai Pharmaceutical Co., Ltd were recalled Subsequently, the international investigation expanded to all the manufacturers of APIs and finished products of Shatan, and more valsartan, irbesartan and losartan containing NDMA and N-nitrosodiethylamine (NDEA) were recalled More than 75 batches of these common high blood pressure drugs have been recalled in recent years, all because they contain impurities that can cause cancer Isotretinoin has been widely used in the treatment of acne for more than 30 years However, it was recalled after thousands of lawsuits and millions of damages The recall statement showed that it had a variety of adverse reactions Photo source: Internet Source: wikihundred Using retinoic acid increases the risk of inflammatory bowel disease and suicide The use of retinoic acid in pregnant women may lead to abortion, premature delivery and congenital heart disease in children Isotretinoin, a prescription drug produced by Roche, was launched in the 1980s, mainly for the treatment of severe acne However, in the more than 30 years since its launch, Roche has received 66 cases of severe skin reactions in adults and children, including 2 deaths As of 2007, 26 people who had taken rocotan had killed themselves in the UK In 2012, 15 teenagers in the UK committed suicide by taking rocotan In 2015, a 15-year-old girl in the UK caused serious side effects after taking rocotan During the treatment, she lost 92% of her pancreas, nearly died six times, and was never pregnant again Finally, Roche completely terminated the production of the product Similar imitations are still in production but their application has been strictly restricted Vioxx (general name: rofecoxib) is a non steroidal anti-inflammatory drug produced by Merck and once popular It was approved by FDA in May 1999 Photo source: Internet In more than four years of marketing, rofecoxib has reported nearly 28000 cases of cardiac death or heart disease The average probability of heart disease was 4 / 1000 The recall was due to the study of wanluo in the prevention of adenopolypoma (approve), which showed that patients taking rofecoxib had a relatively increased risk of certain cardiovascular events (such as heart disease and stroke) after 18 months of treatment compared with placebo group On September 30, 2004, Merck announced the voluntary withdrawal of wanluo Before that, about 80 million patients in the world had taken the medicine, and wanluo's sales in 2003 reached 2.5 billion US dollars It could be the biggest recall of prescription drugs in history Legizumab or raptiva is a kind of psoriasis treatment drug, which is found in clinical application to cause a brain infection called leukoencephalopathy, which is extremely rare but fatal What's more, leukoencephalopathy causes leukoencephalitis, which leads to the damage of leukoencephalon and finally affects the central nervous system In early 2009, the FDA issued a public health guidance that warned the healthcare community about rapiva Subsequently, the manufacturer voluntarily recalled the product On February 19, 2009, the U.S FDA issued a statement saying that three people have died of progressive multifocal leukoencephalopathy (PML) due to the use of the drug, and another one is suspected to have the disease All four have been using the drug for more than three years; on the same day, the European Commission (CHMP) issued a proposal to suspend raptiva's marketing in EU Member States On May 12, 2009, the raptiva right holder, Serono, Switzerland, voluntarily withdrew the right to sell the product Propofol, as a common painkiller, can induce serious cardiac rhythm disorder, and its recall has aroused great public concern Photo source: Wikipedia Propoxyphene was first synthesized by Lilly company Because its clinical effect is similar to that of cocaine, but its addiction is small, and it has been sold well for 20 years Later, Lilly transferred its brand to xanodyne pharmaceutical company At the same time, there are many generic drugs in the market However, in 2006, public citizen, an American consumer rights organization, submitted a request to FDA, claiming that propofol will produce a cardiotoxic metabolite, METHOXYPHENOL, which has caused 2110 accidental deaths in the United States from 1981 to 1999 In 2010, the U.S FDA announced that it would withdraw propoxyphene from the U.S market, so xanodeyne pharmaceutical company withdrew its brand of opioids Later, the FDA asked the drug's imitation propofol hydrochloride to be removed from the shelves as soon as possible, as xanadeyne did Lipitor's direct competition for bestin is used to treat hyperlipidemia and prevent heart disease Bayer produced the drug in the 1990s, but it wasn't on the market until 2001 The risk of inducing rhabdomyolysis, which in turn blocks the glomeruli and leads to renal failure, is shown by the use of the bistein Photo source: Internet Photo source: Wikipedia In 2001, more than 400 cases of rhabdomyolysis were found among the patients taking different doses of cilastatin in the United States, 31 of them died In other countries, 21 cases of fatal rhabdomyolysis caused by xilvastatin were reported On August 8, 2001, Bayer pharmaceutical company announced the withdrawal of silivavastatin from the international drug market, and FDA expressed support for the decision On August 9, China's State Food and drug administration immediately issued an urgent notice banning the use of xilivavastatin The incident made Bayer the first pharmaceutical company in China to voluntarily recall drugs.