Does a longer reproductive period make women more at risk of Alzheimer's disease?

Estrogen is thought to play a role in the risk of Alzheimer's disease (AD) in women
.

A new study takes a different approach to determining risk factors for AD, examining the association between the fertility period of women as an indicator of endogenous estrogen exposure and the level of CSF biomarkers

Menopause: The Journal of the North American Menopause Society

Alzheimer's disease accounts for 60% to 70% of all dementia diagnoses , making it the most common form of dementia
.

Approximately two thirds of AD patients are women

Age at

Despite so much conflicting evidence, few studies have studied the relationship between estrogen and AD biomarkers in the cerebrospinal fluid, which is a clear body fluid found in the tissues surrounding the brain and spinal cord
.

In this new study, a small group of women who did not have dementia and experienced natural menopause were followed for 25 years

Despite so much conflicting evidence, few studies have studied the relationship between estrogen and AD biomarkers in cerebrospinal fluid.

There is a correlation between the duration of reproductive life (surrogate markers of exposure to endogenous estrogen) and Alzheimer's disease biomarkers in the cerebrospinal fluid of women without dementia

This study showed that women with longer fertile periods have a higher risk of dementia in old age compared with women with shorter fertility periods
.

The study, now published in Alzheimer's & Dementia, covers 1364 women who were followed in the population study between 1968 and 2012

Compared with women with shorter reproductive periods, women with longer reproductive periods have a higher risk of developing dementia in old age

Among the women with a short childbearing period (32.
6 years or younger) studied, 16% (53/333) developed dementia
.

In the group of women who had a longer childbirth (38 years or older), 24% (88/364) had dementia

The study shows that for every additional year of birth, the risk of dementia and Alzheimer's disease continues to increase
.

For patients with dementia after the age of 85, this association is strongest, and this effect is most closely associated with menopausal age

After adjusting for other influential factors, these results still exist, such as education, physical activity, BMI, smoking and heart vascular disease
.
On the other hand, no association was found between the risk of dementia and age at menarche, number of pregnancy, duration of breastfeeding, or exogenous estrogen taken in the form of hormone replacement therapy (HRT) or oral contraceptives
.

Heart blood vessels

Some experts say that the different results of estrogen may be because it has a protective effect early in life, but it may be harmful once the disease starts
.

Most women with delayed menopause will not develop dementia because of this factor
.
However, this study may provide a clue as to why women have a higher risk of dementia than men after 85 years of age (the most common age of onset)
.
On the other hand, Alzheimer's disease begins to develop approximately 20 years before symptoms appear
.

As the world ages, the number of people affected by dementia will increase
.
In order to be able to implement prevention strategies, we need to identify people at increased risk of dementia
.

prevention

Reference materials:

Reference materials:

1.
Reproductive period and dementia: A 44-year longitudinal population study of Swedish women.
https://doi.
org/10.
1002/alz.
12118

1.
Reproductive period and dementia: A 44-year longitudinal population study of Swedish women.
https://doi.
org/10.
1002/alz.
12118 Reproductive period and dementia: A 44-year longitudinal population study of Swedish women.
https:/ /doi.
org/10.
1002/alz.
12118

2.
Could a Longer Reproductive Period Put Women at Greater Risk for Alzheimer Disease?http:// 7-7-21.
pdf

2.
Could a Longer Reproductive Period Put Women at Greater Risk for Alzheimer Disease?http:// 7-7-21.
pdf Could a Longer Reproductive Period Put Women at Greater Risk for Alzheimer Disease?http:// -alzheimer-disease-7-7-21.
pdfLeave a message here