-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Diabetic erectile dysfunction (DIED) is considered to be one of the common complications of diabetes (DM)
.
Its pathogenesis may be related to factors such as nerves, blood vessels , vascular endothelium, and endocrine
Diabetic blood vessels In today’s society, the incidence of erectile dysfunction (ED) in male DM patients has reached 35%~90%, which is 1.
As an important intracellular signal transduction pathway, the protein kinase C (PKC) signaling pathway plays a key role in cell apoptosis, neural excitability, cell proliferation and differentiation, gene expression, and cell necrosis
Materials and methods: The chemical components of Huoxue Tongluo Qiwei Decoction were identified by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
.
Streptozotocin (STZ) induced rat model, apomorphine (APO) screening
Materials and methods: Immunization
The results of the study showed that the serum levels of sE-selectin, LOX-1, intercellular adhesion molecule-1 (sICAM-1), endothelial microparticles (EMPs), P-selectin (CD62P) and MDA in group M rats were significant It was higher than that of rats in group K, and the level of superoxide dismutase (SOD) decreased significantly
.
In addition, the PKC pathway is activated, and the expression of related proteins and mRNA increases
research shows
Positive ion chromatography analysis of Huoxuetongluoqiweitang based on HPLC-MS/MS:
Positive ion chromatography analysis of Huoxuetongluoqiweitang based on HPLC-MS/MS:
In summary, it is found that the mechanism of DIED is related to vascular endothelial injury and abnormal platelet activation caused by activation of PKCβ signaling pathway
.
Huoxue Tongluo Qiwei Decoction can inhibit the protein and mRNA expression of PKCβ signaling pathway related molecules in DIED rats, promote vascular endothelial damage, enhance antioxidant capacity, and prevent platelet activation, thereby improving the erectile function of DIED rats
It is found that the mechanism of DIED is related to abnormal platelet activation caused by vascular endothelial injury and activation of PKCβ signaling pathway
Original: Li X, Feng JL, Chen ZL, Bao BH, Dai HH, Meng FC, Deng S, Wang B, Li HS, Wang JS.
Leave a message here
