Does common cold virus change treatment way of bladder cancer thoroughly? Clinical early

Kill T cells around cancer cellsImage source: NIH < br / > non muscle invasive bladder cancer (NMIBC) is a cancer in which the focus is located in the inner surface of the bladderThis kind of cancer has always been difficult to treat and easy to recurThe treatment methods include transurethral resection of bladder tumor and BCG induced immunotherapy< br / > transurethral resection is an invasive operation to remove all visible lesionsHowever, the recurrence rate of the tumor still varies from 50% to 70%; in two to five years, the progression rate of the tumor varies from 10% to 20%On the other hand, BCG induced immunotherapy showed that one third of the patients had serious side effects and one third of the patients were ineffectiveTherefore, more effective and safe new therapy for NMIBC remains to be studied< br / > recently, researchers from the University of Surrey and the Royal Hospital of Surrey in the UK investigated the safety and tolerability of a oncolytic virus, Coxsackie virus (cva21), in the treatment of 15 patients with NMIBCThe results were published in the latest issue of clinical cancer research< br / > doi: 10.1158/1078-0432.ccr-18-4022 < br / > light of hope? < br / > oncolytic virus is a naturally occurring common cold virusThrough infection, they can destroy tumor cells and stimulate host anti-tumor immune response to prevent the growth of tumor cells, so they are regarded as "anti-cancer" virusesIn this pioneering study, 15 patients with NMIBC received cva21 treatment through a bladder catheter one week before the scheduled surgical removal of the tumor< br / > after the operation, by examining tissue samples, the researchers found that cva21 was highly selective, targeting only cancer cells in organs, while all other cells were intactIt infects cancer cells and replicates itself, causing them to rupture and dieThe next day, urine samples collected from patients detected virus "shedding", indicating that once the cancer cells infected by the virus die, the newly replicated virus will continue to attack other cancer cells in the organ< br / > the bladder usually has no immune cells, so it can not eliminate the tumor itself These tumors, which lack immune cells, are known as "cold zones" in immunology; the evidence in this study shows that the use of cva21 treatment can cause tumor inflammation, leading to immune cells rushing to the cancer environment, targeting and killing cancer cells Inflammation and immune cell stimulation caused by viral therapy can be regarded as "immune fever" This "hot" tumor is more likely to be rejected by the immune system < br / > after cva21 treatment, most of the patients observed a reduction in tumor burden and an increase in cancer cell death, and all the cancer signs disappeared in one patient, and no significant side effects were observed in the patients receiving cva21 treatment < br / > Dr Nicola annels, a researcher at the University of Surrey, said: "viruses are usually associated with diseases, but when appropriate, they can improve our overall health and quality of life by destroying cancer cells Oncolytic viruses such as the Coxsackie virus may change the way we treat cancer and may mark our abandonment of more traditional treatments such as chemotherapy " < br / > pour a little cold water < br / > although the research results show great potential, the research is still in the preliminary clinical stage, and its mechanism is not clear It is a long time to go through a large number of clinical trials and effective research of combined treatment to clinical application or new drugs on the market The way to go < br / > it is not recommended for some patients to catch cold or Coxsackie virus with the mentality of "dead horse being a live horse doctor" The experiment is well designed The Coxsackie virus is not a cold virus < br / > Coxsackie virus, divided into a and B categories The typical symptoms of coxsackievirus a are herpetic angina, lymphofollicular hyperplasia, exudation, tonsil enlargement, etc.; the infection of coxsackievirus B causes characteristic infectious chest costalgia, which can be combined with meningeal encephalitis, myocarditis, fever, Guillain Ba RR é syndrome, hepatitis, hemolytic anemia and pneumonia Conclusion < br / > the research is to be expected, scientific and not biased What's more, we should take care of ourselves in daily life, have regular physical examination, and take preventive measures < br / > the original title: "common cold virus completely changes the treatment of bladder cancer" -- the study is still early