Does the new coronavirus transmit vertically from mother to child? Liu Ye Dao: no evidence found yet

Authors: the novel coronavirus outbreak of Gu Lu Lu is still spreading Recently, WHO named novel coronavirus "SARS-CoV-2", named "COVID-19" by the virus infected The novel coronavirus is still unknown, including whether pregnant women infected with the virus can transmit the virus to the fetus On February 5, Wuhan children's hospital confirmed two cases of neonatal pneumonia with coronavirus infection The youngest baby was born only 30 hours later The novel coronavirus pneumonia was diagnosed in February 2, 2020 A novel coronavirus nucleic acid test was carried out on infants 30 hours after birth Experts consider that novel coronavirus may have a new transmission route - mother infant vertical transmission Https://doi.org/10.1016/s0140-6736 (20) 30360-3 a retrospective study published in the lancet on February 12 assessed the clinical characteristics of covid-19 during pregnancy and the possibility of mother to child vertical transmission This study analyzed the medical records of 9 pregnant women (age range: 26-40 years old, 36-39 weeks + 4 days) who were admitted to Central South Hospital of Wuhan University from January 20 to January 31, 2020 All patients had no underlying diseases (such as diabetes, chronic hypertension or cardiovascular disease) All patients had a C-section in the third trimester Seven of them had fever (none of them had high fever, i.e the temperature was more than 39 ℃), and the temperature of the patients fluctuated in the range of 36.5-38.8 ° C Two patients with normal body temperature before laparotomy had postpartum fever (range 37.8-39.3 ° C) At the same time, other symptoms of upper respiratory tract infection were observed: cough (4 cases), myalgia (3 cases), sore throat (2 cases), discomfort (2 cases) Five of the nine patients had lymphocytopenia (L < 1.0 × 10 ^ cells) Transaminase concentration increased in 3 patients Chest CT scan of 9 patients 4 of 9 patients were born prematurely (all more than 36 weeks of gestation), but the cause of prematurity was not related to covid-19 pneumonia As of February 4, 2020, no severe pneumonia or death had occurred in all patients, and all newborns survived Neonatal outcome when the women delivered by caesarean section, doctors collected samples of amniotic fluid, cord blood, and throat swabs In addition, breast milk samples were collected from patients after their first lactation All of these samples were collected in the operating room at the time of birth to ensure that they were not contaminated and best represented the condition of the fetus in the womb, the researchers said The results showed that sars-cov-2 was negative in all the samples This also means that there is no evidence that patients with covid-19 pneumonia in the third trimester can cause adverse neonatal outcomes through intrauterine vertical transmission It should be noted, however, that the study was small and involved only pregnant women who delivered by caesarean section in the third trimester Zhang Yuanzhen, the lead author of the study and a professor at Central South Hospital of Wuhan University in China, said in a statement that in the initial case, pregnant women had fever for 8 hours and were suspected of having covid-19 pneumonia based on CT images before admission Then an emergency caesarean section was performed and confirmed In addition, throat swab samples of newborns were collected about 30 hours after birth, so no direct evidence of intrauterine infection was provided In addition, no direct test was conducted on intrauterine tissue samples (such as amniotic fluid, cord blood or placenta) to determine whether the newborn's covid-19 infection was due to intrauterine transmission However, this case of neonatal infection shows that we should pay special attention to prevent neonatal infection of mothers with covid-19 pneumonia The authors conclude that pregnant women with covid-19 pneumonia have a variety of symptoms, the main symptoms of which are fever and cough We found no evidence of vertical transmission in late pregnancy Although the study received a limited number of samples, the results are important for understanding the clinical characteristics and vertical transmission potential of covid-19 infection in pregnant women Reference: [1] can precursor mom pass coronavirus to her unborn child? Early research says no [2] clinical characteristics and Intranet vertical transmission potential of covid-19 infection in nine premier women: a retrospective review of medical records [3] The lancet released a study of nine pregnant women infected with new coronavirus, but no evidence of mother to child vertical transmission has been found