DOM: A low n-6/n-3 polyunsaturated fatty acid ratio diet improves hyperinsulinemia by restoring insulin clearance in obese youth

Background: Hyperinsulinemia due to reduced insulin clearance and excess insulin secretion is a key feature of insulin resistance and is influenced by multiple factors, such as hepatic response to insulin action, dietary and circulating fat, and ethnic background

Background: Hyperinsulinemia due to reduced insulin clearance and excess insulin secretion is a key feature of insulin resistance and is influenced by multiple factors, such as hepatic response to insulin action, dietary and circulating fat, and ethnic background

Objectives: Here, we tested the hypothesis that, in the absence of significant changes in body weight, a low n–6:n–3 PUFA ratio diet could alter the metabolic phenotype of obese youth with NAFLD by increasing insulin clearance

Materials and methods

result

Figure 1 Plasma insulin (A), glucose (B) and C-peptide concentrations (C); insulin secretion rate (ISR) (D); 180-minute area under the curve of ISR (AUC0-180 minutes) (E); relative to plasma ISR of glucose (F); β-cell glucose sensitivity (β-GS) (G); ISR at a fixed fasting glucose of 5 mmol/L (ISR @ 5) (H); β-cell rate sensitivity (β-RS) ) (I); enhancer factor ratios at 120 minutes (J) and 180 minutes (K); fasting insulin clearance (L), oral glucose tolerance test (OGTT) (M), and percent reduction from fasting to OGTT ( N); Oral Glucose Insulin Sensitivity (OGIS) Index (O) in obese youth at baseline (week 0) and after a low n–6:n–3 PUFA ratio diet (week 12)

Figure 1 Plasma insulin (A), glucose (B) and C-peptide concentrations (C); insulin secretion rate (ISR) (D); 180-minute area under the curve of ISR (AUC0-180 minutes) (E); relative to plasma ISR of glucose (F); β-cell glucose sensitivity (β-GS) (G); ISR at a fixed fasting glucose of 5 mmol/L (ISR @ 5) (H); β-cell rate sensitivity (β-RS) ) (I); enhancer factor ratios at 120 minutes (J) and 180 minutes (K); fasting insulin clearance (L), oral glucose tolerance test (OGTT) (M), and percent reduction from fasting to OGTT ( N); Oral Glucose Insulin Sensitivity (OGIS) Index (O) in obese youth at baseline (week 0) and after a low n–6:n–3 PUFA ratio diet (week 12)

Figure 2 Correlation between changes in oral glucose insulin sensitivity (OGIS) index and changes in insulin clearance during oral glucose tolerance test (OGTT) (A); changes in liver fat fraction (HFF%) and changes in insulin clearance during OGTT Correlations between changes (B) or changes in OGIS index (C); and between changes in beta-cell glucose sensitivity and changes in insulin clearance during OGTT (D)

Figure 2 Correlation between changes in oral glucose insulin sensitivity (OGIS) index and changes in insulin clearance during oral glucose tolerance test (OGTT) (A); changes in liver fat fraction (HFF%) and changes in insulin clearance during OGTT Correlations between changes (B) or changes in OGIS index (C); and between changes in beta-cell glucose sensitivity and changes in insulin clearance during OGTT (D)

Figure 3 Plasma insulin (A) and glucose (B) in response to a 75 g oral glucose tolerance test (OGTT) at baseline (week 0) and after a low n–6:n–3 PUFA ratio diet (week 12) Concentrations, subjects' post-load insulin clearance increased significantly (>25% of baseline) or changed slightly (25%)

Figure 3 Plasma insulin (A) and glucose (B) in response to a 75 g oral glucose tolerance test (OGTT) at baseline (week 0) and after a low n–6:n–3 PUFA ratio diet (week 12) Concentrations, subjects' post-load insulin clearance increased significantly (>25% of baseline) or changed slightly (25%)

Table 1 Glucose tolerance and insulin metabolism in study participants stratified according to diet-induced changes in post-load insulin clearance at enrollment and after the 12-week intervention

Conclusion

Conclusion

Original source: Tricò D, Galderisi A, Van Name MA, et al.
A low n-6 to n-3 polyunsaturated fatty acid ratio diet improves hyperinsulinemia by restoring insulin clearance in obese youth .
Diabetes Obes Metab 2022 Mar 17 A low n- 6 to n-3 polyunsaturated fatty acid ratio diet improves hyperinsulinemia by restoring insulin clearance in obese youthLeave

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