Dong Jianfei's research group from Suzhou Institute of Medical Technology has made progress in dynamic process analysis and data-driven modeling of phototherapy

Calculating the production of singlet oxygen during PDT and ABL is the key to determining the light dose for these two treatments .

In order to analyze the kinetics of the photo-oxidative reaction in the phototherapy process and propose a simple and effective modeling method, Dong Jianfei's research group applied basic control theory to analyze the process, and obtained the linearization of the first-principles PDT model.

First, the nonlinear first-principles PDT model is linearized at a series of equilibrium points on its trajectory, and a series of linear time-invariant ( LTI ) state-space ( SS ) models are obtained

 Figure 1 Root locus of the linearized model at a series of equilibrium points on the system trajectory: (a) hypoxic, (b) oxygen- enriched 

This is an interesting conclusion

 Fig.

The main innovation of this study is the first application of control theory to analyze the kinetics of photochemical reactions in phototherapy, and the first mathematical model for phototherapy of fungal infections based on endogenous photosensitizers

Paper link: https://ieeexplore.

This research was supported by the National Natural Science Foundation of China General Program ( F030110 : Data-Driven Control)