Dr. Julian quodbach: 3D printing technology provides more possibilities for drug individualization

[interview with people on chinapharma.com] from October 17 to 19, the 16th Shanghai International powder processing / bulk material transportation Exhibition (ipb2018) opened in Shanghai World Expo exhibition hall Exhibitors and visitors from the fields of crushing, grinding, screening, drying, mixing, filtration, transportation, packaging, testing, safety and explosion-proof, etc attended the event This grand meeting not only includes advanced equipment and technical projects of powder industry, but also technical exchange meeting for discussion and learning of the industry On October 17, "the third Shanghai international pharmaceutical powder preparation technology exchange 2018" was held in conference room 6 of Shanghai World Expo exhibition hall Dr Julian quodbach of the school of pharmacy and Biopharmaceutics, University of Dusseldorf, brought the theme sharing of "the application of 3D printing in medicine and other industries" to the audience After the meeting, Dr Julian quodbach gave an interview to chinapharma.com Dr Julian quodbach, School of pharmacy and Biopharmaceutics, University of Dusseldorf, interviewed chinapharma.com about 3D printing technology, which is also known as "additive manufacturing" technology, also known as additive manufacturing or incremental manufacturing Compared with the traditional way of reducing material manufacturing, 3D printing can hardly cause the waste of metal materials, and also can greatly reduce the equipment problems in the production process At present, powder preparation technology has become a hot spot in the field of 3D printing in recent years In response to the above trend, Dr Julian quodbach said that 3D printing is about the individualization of drugs For this technology, the good fluidity of powder is a very important factor, which will make the drugs have uniformity However, in terms of existing technologies, drug individualization is still facing great challenges "There are many problems to overcome, many of which are regulatory issues We don't know how to approve individual drugs to enter the market and how to ensure the safety of the drug " Dr Julian quodbach said that the development of 3D printing equipment currently available is not consistent with GMP, they are usually used to manufacture machinery or other related parts, and the requirements are totally different According to Dr Julian quodbach, there are many different areas where there is room for further development, and unfortunately, it will take even longer "But these issues need to be further explored in future medicine, so as to better provide individualized drugs to patients." This technical exchange meeting is of great significance for the technical analysis between 3D printing and powder preparation It also brings together many experts and scholars at home and abroad For Dr Julian quodbach, this exchange meeting has yielded a lot Dr Julian quodbach said: "the preparation and morphology of the powder are very important to ensure the quality of the drug In this IPB Shanghai powder exhibition, many enterprises are engaged in the research in this field The diversified grinding technology, particle characterization and morphological description presented at the exhibition provide more possibilities for drug individualization They have played a great role in promoting the whole research process " IPB Shanghai powder exhibition presents the new trend, new technology and new equipment in the powder field, which will greatly promote the innovation and development of the whole industry in the future According to Dr Julian quodbach, there are two main approaches to the development of solid dosage forms Specifically speaking, first, as we all know, large-scale manufacturing, such as flat-panel printing machine, can produce 1.5 million tablets per hour, which is suitable for most patients; second, individualized drugs, if they can avoid adverse drug reactions, ensure patients' safety and good treatment effect, will also have good market development opportunities "Both paths can have more in-depth research directions Large scale manufacturing is more dependent on continuous manufacturing, and small scale manufacturing will bring new ideas to the world " Said Dr Julian quodbach.