Original title: Dr. Li Na of the Institute of Tropical Medicine of Hainan Medical College revealed the new mechanism of short Bifidobacteria M-16V to relieve food allergies
as a common allergic disease, has become a serious public health problem endangering the health of adults and children. Due to the repeated symptoms of food allergies, and at this stage there is no complete cure, seriously reduce the quality of life of patients, to the family and society to bring a huge mental and financial burden. Therefore, it is particularly important for food allergy prevention and treatment to clarify the pathogenesis of food allergies and find effective ways to alleviate and treat them. Probiotics, as the balancer of intestinal micro-ecology and the regulator of immune function, can effectively relieve the symptoms of allergies in the body.
recently, Dr. Li Na of the Institute of Tropical Medicine of Hainan Medical College revealed a new mechanism for food allergy relief of short
M-16V (Bb M-16V), the results of which were published in May 2020 in the journal JOURNAL OF CELLULAR, a journal of WILEY. PHYSIOLOGY (IF: 5.546) is published online under the title "Bifidobacterium Breve M-16V Alters the Gut Microbiota to Alleviate OVA-Induced Food Allergy Through IL-33/ST2 Pathway". Professor Xu Chunxuan of Ruijin Hospital, Shanghai Jiaoxuan University, is the author of the paper. Dr. Li Na of the Institute of Tropical Medicine of our university and Dr. Yu Wei, Deputy Director of Ruijin Hospital, Shanghai Jiaoyu University, are the co-authors of the paper.
With support from the China Postdoctoral Fund, the team found that Bb M-16V significantly improved the small intestine inflammatory response induced by egg white protein in mice, reducing the immersion of inflammatory cells, and significantly inhibited serum IL-4 and IL-4/IFN-γ secretion levels, with no significant effect on IL-5 and IL-13. Although Bb M-16V was given no significant inhibitory effect on the expression of small intestine IL-33 during food allergy, it significantly blocked the expression of IL-33 subject ST2, affecting not only the whole body Th2 reaction, but also significantly reducing the severity of the allergic reaction. After discussing the immune effects of Bb M-16V, the team tested the effects of Bb M-16V on the gut microbioty in allergic mice. Studies have shown that Bb M-16V can adjust the composition of the gut bacteri group, and these changes are closely related to the expression of immune factors.
Based on the close relationship between Bifidobacteria and food allergies, this study explores the regulatory role of Bb M-16V on intestinal bacteria and immune function in food-allergy mice by establishing a model of food-allergic mice, and reveals the composition of different intestinal bacteria after allergen exposure. In regulating the response of T cells to intestinal allergic reactions, the results provide a new basis for the application of Bb M-16V in food allergies, provide new ideas for accurate diagnosis and targeted treatment of food allergies, and provide new strategies for effectively reducing the occurrence of food allergies.