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PARPs (Poly (ADP-ribose) polymerase) are a class of protein superfamily responsible for transferring ADP-ribose groups to target proteins and modifying target proteins by ADP ribosylation (ADPr).
They are widely involved in DNA damage repair.
Transcription regulation, chromosomal protein remodeling and other important biological processes
.
Recent studies have shown that PARPs not only play an irreplaceable role in maintaining genome stability and regulating signal pathways, but also play an important role in regulating the body's natural immune response
.
Recently, Dr.
Zhu Huifang from the First Affiliated Hospital of Gannan Medical College published a review paper titled: The Critical Role of PARPs in Regulating Innate ImmuneResponses in Frontiers in Immunology
.
The latest research progress in related fields was systematically reviewed, and the molecular mechanisms of PARPs in regulating tumors, viral infections, inflammation, and cellular emergency stress-related innate immune responses were summarized
.
The first author of this review is Dr.
Zhu Huifang (Bachelor of Shenyang Pharmaceutical University, Master of Wuhan Institute of Virology, Chinese Academy of Sciences, Ph.
D of Kunming Institute of Botany, Chinese Academy of Sciences), First Affiliated Hospital of Gannan Medical College, Children's Medical Center, Department of Neonatology, Lecturer; concurrently served as Gannan Medicine College, Basic Medical College, Master's degree tutor
.
The main research directions include the exploration of the molecular mechanism of antiviral natural immunity and the immunotherapy of childhood leukemia tumors
.
The corresponding author is Professor Chunfu Zheng.
Professor Chunfu Zheng is the editor of mBio (zero breakthrough of Chinese local editors), and the editorial board member of Journal of Virology (one of the first two selected Chinese local editors); he also serves as Frontiers in Microbiology, Virology Journal, Associate editor of Journal of Medical Virology and guest editor of Frontiers in Immunology
.
Professor Zheng Chunfu has made breakthrough research results in the study of the molecular mechanism of the interaction between herpes simplex virus type I (HSV-1) infection and the host, and the study of HSV-1 escape host antiviral innate immunity.
In Trends in Microbiology (IF=17.
079), Microbiology and Molecular Biology Reviews (cover article, IF=12.
568), FEMS MicrobiologyReviews (IF=16.
408), Blood (IF=22.
169), CellHost & Microbe (IF=21.
023), PNAS (IF=11.
205), Protein and Cell (IF= 14.
870; 2 articles), mBio (IF=7.
867), Cytokine& Growth Factor Reviews (IF=7.
658), Journal of Virology (23 articles, 2 of which are highlight articles; IF=5.
103), Journal of Immunology (2 articles, IF =5.
422) and other mainstream journals have published more than 100 SCI papers, with a total number of citations of more than 2,300, and an H-index of 28
.
Laboratory website: https://bms.
fjmu.
edu.
cn/2017/1130/c2905a72170/page.
htm The call for papers on Frontiers in Microbiology by Professor Chunfu Zheng is still in progress, and the current deadline is October 31
.
15 articles have been published and 5 articles are under review
.
https:// full text link: https://pubmed.
ncbi.
nlm.
nih.
gov/34367175/Frontiers inImmunology ("Frontiers in Immunology") is a peer-reviewed open-access journal and an official journal of the International Union of Immunological Societies (IUIS), with the latest impact factor of 7.
6 in 2020
.
The journal aims to publish the most outstanding research results covering the entire field of immunology
.
In addition to the research papers on the basic mechanisms of the development and function of the immune system, it also emphasizes the description of the clinical and immunophenotypes of human immune diseases, as well as the definition of their molecular basis
.
For more details about Frontiers inImmunology, please click "Read the original text" to visit the official website
.
Headquartered in Switzerland, Frontiers is the world's leading Open Access publisher, committed to making science more open globally
.
They are widely involved in DNA damage repair.
Transcription regulation, chromosomal protein remodeling and other important biological processes
.
Recent studies have shown that PARPs not only play an irreplaceable role in maintaining genome stability and regulating signal pathways, but also play an important role in regulating the body's natural immune response
.
Recently, Dr.
Zhu Huifang from the First Affiliated Hospital of Gannan Medical College published a review paper titled: The Critical Role of PARPs in Regulating Innate ImmuneResponses in Frontiers in Immunology
.
The latest research progress in related fields was systematically reviewed, and the molecular mechanisms of PARPs in regulating tumors, viral infections, inflammation, and cellular emergency stress-related innate immune responses were summarized
.
The first author of this review is Dr.
Zhu Huifang (Bachelor of Shenyang Pharmaceutical University, Master of Wuhan Institute of Virology, Chinese Academy of Sciences, Ph.
D of Kunming Institute of Botany, Chinese Academy of Sciences), First Affiliated Hospital of Gannan Medical College, Children's Medical Center, Department of Neonatology, Lecturer; concurrently served as Gannan Medicine College, Basic Medical College, Master's degree tutor
.
The main research directions include the exploration of the molecular mechanism of antiviral natural immunity and the immunotherapy of childhood leukemia tumors
.
The corresponding author is Professor Chunfu Zheng.
Professor Chunfu Zheng is the editor of mBio (zero breakthrough of Chinese local editors), and the editorial board member of Journal of Virology (one of the first two selected Chinese local editors); he also serves as Frontiers in Microbiology, Virology Journal, Associate editor of Journal of Medical Virology and guest editor of Frontiers in Immunology
.
Professor Zheng Chunfu has made breakthrough research results in the study of the molecular mechanism of the interaction between herpes simplex virus type I (HSV-1) infection and the host, and the study of HSV-1 escape host antiviral innate immunity.
In Trends in Microbiology (IF=17.
079), Microbiology and Molecular Biology Reviews (cover article, IF=12.
568), FEMS MicrobiologyReviews (IF=16.
408), Blood (IF=22.
169), CellHost & Microbe (IF=21.
023), PNAS (IF=11.
205), Protein and Cell (IF= 14.
870; 2 articles), mBio (IF=7.
867), Cytokine& Growth Factor Reviews (IF=7.
658), Journal of Virology (23 articles, 2 of which are highlight articles; IF=5.
103), Journal of Immunology (2 articles, IF =5.
422) and other mainstream journals have published more than 100 SCI papers, with a total number of citations of more than 2,300, and an H-index of 28
.
Laboratory website: https://bms.
fjmu.
edu.
cn/2017/1130/c2905a72170/page.
htm The call for papers on Frontiers in Microbiology by Professor Chunfu Zheng is still in progress, and the current deadline is October 31
.
15 articles have been published and 5 articles are under review
.
https:// full text link: https://pubmed.
ncbi.
nlm.
nih.
gov/34367175/Frontiers inImmunology ("Frontiers in Immunology") is a peer-reviewed open-access journal and an official journal of the International Union of Immunological Societies (IUIS), with the latest impact factor of 7.
6 in 2020
.
The journal aims to publish the most outstanding research results covering the entire field of immunology
.
In addition to the research papers on the basic mechanisms of the development and function of the immune system, it also emphasizes the description of the clinical and immunophenotypes of human immune diseases, as well as the definition of their molecular basis
.
For more details about Frontiers inImmunology, please click "Read the original text" to visit the official website
.
Headquartered in Switzerland, Frontiers is the world's leading Open Access publisher, committed to making science more open globally
.
