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Background: Type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders, and glycemic control usually begins with oral hypoglycemic drugs
Objective: The objective of this study was to analyze the efficacy, insulin sensitivity and safety
Methods: A randomized, open-ended, parallel, 16-week trial was conducted in four research centers
Results: Compared with the G group, HbA1c and PPG 2 h in the G/M group were significantly reduced
Table 1 - Insulin glargine dose control algorithm
Table 2 Equivalence and power analysis of endpoint parameter changes
Table 3 Endpoint Response Rate (ITT
Conclusions: A comparison of combination therapies consisting of either the G/M group or the G group showed that both forms of treatment were relatively safe, but the former was more effective at lowering blood glucose levels
Original source :Yu HM, Kim SJ, Chun SW, et al.