Drinking too much coffee increases dementia risk by 53%

Coffee is one of the most popular non-alcoholic beverages after water, with more than 9 billion kilograms consumed globally each year
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Coffee contains caffeine, which is a central nervous system stimulant
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Due to its high lipid solubility and structural similarity to adenosine, caffeine readily crosses the blood-brain barrier and competes with adenosine receptors for binding
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It stimulates the adrenal glands to secrete catecholamines, which are excitatory neurotransmitters that mediate effects on cognition, mood, and motor function
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 Therefore, caffeine has a wide range of physiological effects, affecting sleep patterns, mood, motor activity, heart rate, body temperature and oxygen consumption
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Compiled and organized by Yimaitong, please do not reprint without authorization
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STUDY INTRODUCTION Previous studies have shown that there are several mechanisms that may modulate the potential effects of coffee on brain morphology, dementia and stroke risk
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For example, changes in brain volume may be due to caffeine binding to antagonists of adenosine receptors, which induce morphological changes and reduced information transmission in mossy fibers or pyramidal cells
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However, only a few studies have looked at the association between coffee intake and brain volume
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Another area of ​​interest in the brain is white matter hyperintensity (WMH), a small lesion often associated with localized small blood vessel damage, associated with increased risk of stroke and dementia
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In a recent study, increased coffee consumption in older women was associated with lower levels of WMH, but not in men
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The researchers believe that blocking adenosine receptors with higher coffee intake may reduce the accumulation of amyloid in the brain, thereby reducing WMH production
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The researchers conducted a prospective analysis of habitual coffee consumption in 398,646 UK Biobank participants (aged 37-73), including 17,702 with MRI information
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Associations with brain volume were assessed using covariate-adjusted linear regression, and odds of dementia (4,333 events) and stroke (6,181 events) were assessed using logistic regression
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Main findings: ➤ Habitual coffee drinking was associated with whole brain volume (per cup fully adjusted β -1.
42, 95% CI -1.
89, -0.
94), gray matter (β -0.
91, 95% CI -1.
20, -0.
62), white matter (β -0.
91, 95% CI -1.
20, -0.
62) There was a negative linear association between -0.
51, 95% CI -0.
83, -0.
19) and hippocampal volume (β -0.
01, 95% CI -0.
02, -0.
003), but there was no evidence to support an association with WMH volume (β -0.
01, 95 %CI -0.
07, 0.
05)
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➤ The association between coffee intake and dementia was non-linear (P non-linear = 0.
0001), with evidence that non-coffee drinkers and those who drank more than 6 cups of The odds are higher
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After full covariate adjustment, drinking > 6 cups/day was associated with a 53% higher odds of dementia (fully adjusted OR 1.
53, 95% CI 1.
28, 1.
83) compared with 1-2 cups/day, and the evidence of association with stroke was higher.
less (OR 1.
17, 95%CI 1.
00, 1.
37, p = 0.
055)
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Study Conclusions In this large, heterogeneous sample of longitudinal data, the researchers found that higher coffee intake was linearly associated with smaller whole brain, gray matter, white matter and hippocampal volumes, and the study also supports the possibility that higher coffee intake may be Hypotheses linked to increased odds of dementia
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These findings suggest that high coffee intake may increase the risk of dementia
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Yimaitong compiled from: Kitty Pham, Anwar Mulugeta, Ang Zhou, John T.
O'Brien, David J.
Llewellyn & Elina Hyppönen (2021): High coffee consumption, brain volume and risk of dementia and stroke, Nutritional Neuroscience, DOI : 10.
1080/1028415X.
2021.
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