Drinking too much tea will increase uric acid?

*For medical professionals to read and reference only I heard that people like drinking beer and eating seafood are prone to high uric acid.
How can they drink tea? When it comes to provinces that love tea, Guangdong will definitely be in the top three
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As the saying goes, "three teas, two meals, and one night snack", Cantonese people's whole day's sense of ritual begins with "morning tea", followed by afternoon tea and night tea
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 Drinking tea can cultivate one's body and nourish one's body and remove the impetuousness from the body, but drinking too much tea may also lead to an increase in uric acid.
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.
What's going on? Recently, a study published in the International Journal of General Medicine showed that the frequency of tea drinking in the Guangdong labor force was associated with an increased risk of hyperuricemia, and this was more pronounced in men than in women
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Figure 1 Screenshot of the literature Drinking tea can also increase uric acid, which is more serious in men As a result, the frequency of tea drinking among these participants was divided into three categories: never, once a month to twice a week, and ≥3 times a week
.

 To add rigour to the findings, the study constructed three models to investigate the effect of tea intake on the risk of hyperuricemia
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 The first model was adjusted for age, sex, and body mass index (BMI); the second model was further adjusted for serum creatinine (SCr), cholesterol (CHOL), triglycerides (TG), low-density lipoprotein cholesterol ( LDL-C), high-density lipoprotein cholesterol (HDL-C) and fasting blood glucose (FBG), and hypertension; the third model builds on Model 2 by adding education level, smoking status, alcohol consumption, salty taste Adjustments were made for diet, late-night snacking, overeating, frequency of eating out, frequency of grilled or fried foods, and frequency of savory or smoked foods
.

A P value of <0.
05 was considered statistically significant.
The results showed that among the 7644 study participants, a total of 3149 participants currently had hyperuricemia, and the males (77.
7%) were significantly higher than the females (22.
3%) (Fig.
2, Figure 3)
.

 Figure 2 Rough and adjusted odds ratios for hyperuricemia based on tea drinking in menFigure 3 Rough and adjusted odds ratios for hyperuricemia based on tea drinking in women In terms of tea intake, Whether it is *univariate logistic regression analysis results or *multivariate logistic regression analysis results based on the frequency of tea drinking in the three models, it shows that there is a significant correlation with hyperuricemia, and tea drinking is also considered to be a Independent risk factors for hyperuricemia
.

 First look at the univariate logistic regression results: participants who drank tea once a month to twice a week had a 1.
744 risk of exposure to hyperuricemia compared with those who never drank tea [OR 1.
744, 95% CI (1.
481-2.
0539)]; and participants who drank tea ≥3 times per week had a higher exposure risk of hyperuricemia compared with those who never drank tea 2.
444 [OR 2.
444, 95% CI (2.
070-2.
886)] (Table 1)
.

Note: OR is used to reflect the strength of the association between exposure factors and outcome events
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The advantage of OR is that it is not affected by prevalence (ie, the ratio of the case group to the control group)
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The larger the value, the greater the effect of the exposure and the stronger the association between the exposure and the outcome
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If RR or OR=1, it means that there is no association between exposure factors and disease; if >1, it means that exposure factors are positively related to disease; if <1, it means that exposure factors are negatively related to disease (protective factors)
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 Table 1 Comparison of some features of hyperuricemia using a univariate logistic regression model *Univariate logistic regression analysis (examines the gender, age, education level, smoking history, relationship between tea intake and other dietary factors, etc.
)
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 Let's look at the multivariate logistic regression analysis results: compared with the control group, the adjusted value of the risk of hyperuricemia exposure for the participants who drank tea once a month to twice a week was 1.
30 [OR 1.
30, 95%CI (1.
08 –1.
56), P=0.
006], while participants who drank tea ≥3 times a week had an adjusted risk of hyperuricemia exposure of 1.
35 [OR 1.
35, 95%CI (1.
11–1.
64), P=0.
003]
.

(Table 2) Table 2 Raw and adjusted odds ratios (95% CI) for hyperuricemia based on tea consumption and BMI were adjusted; the second model was further adjusted for SCr (μmol/L), CHOL (mmol/L), TG (mmol/L), LDL-C (mmol/L), HDL-C (mmol/L) , FBG (mmol/L), and hypertension; the third model for Model 2 plus education level, smoking status, alcohol consumption, salty diet, late night snacks, overeating, frequency of eating out, frequency of grilled or fried food intake And the frequency of salty or smoked food intake was adjusted
.

 It can be seen that there is a positive correlation between the frequency of tea drinking and the risk of hyperuricemia among the working population in Guangdong Province, and the higher the tea intake, the higher the risk of hyperuricemia.
big
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It can also be seen from the subgroup analysis that this effect is more pronounced in men than in women
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 So, if you encounter a patient in the clinic and ask him with his physical examination report: "Doctor, I usually keep a good health, I don't drink, don't smoke, and I'm not big fish, how can I get high uric acid in the physical examination? "At this time, you may ask the patient if he or she likes to drink tea
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 According to this study, the frequency of drinking tea is positively correlated with the risk of hyperuricemia among the Chinese working population in Guangdong Province.
Based on this, I would like to ask you to share how this group of people should drink tea.
? According to the recommendations of domestic and foreign guidelines, Professor Li Jia recommends the following aspects for tea drinking with hyperuricemia: 1.
Tea should be mainly light tea, not strong tea.
Taking water consumption as an example, you can drink 6-8 cups of tea per day.
2.
When drinking tea, high-purine diet is not recommended.
For example, two cups and one cup of Cantonese people’s morning tea habits include animal offal, various boat porridge with old fire soup as the base, preserved egg and lean meat porridge, etc.
high purine.
Food; 3.
Drinking tea, the tea here usually refers to green tea, black tea, etc.
, rather than various tea drinks, because tea drinks are usually added with high sugar or fructose to improve the taste, not real tea
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What are the clinical guiding significance of this study for the prevention and treatment of clinical hyperuricemia? Professor Li Jia This is a very good study, which has put forward a good discussion on the risk of drinking "tea" and hyperuricemia in the dietary habits of Cantonese people
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In the form of questionnaires, three groups of people with different frequency of drinking "tea": never, once a month to twice a week, ≥ 3 times a week and the risk of hyperuricemia were discussed
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The traditional concept believes that the low purine content of tea water can even reduce uric acid, based on: 1.
Tea contains tea polyphenols or theophylline, which has the effect of reducing uric acid, but in fact, the concentration of tea polyphenols or theophylline in weak tea is not enough to achieve The effect of reducing uric acid requires long-term drinking to have a certain effect; 2.
Tea, especially weak tea, is mainly water, and like drinking a lot of water, it can promote the excretion of uric acid
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However, it is widely recognized that strong tea affects uric acid excretion
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This paper uses Cantonese people to drink "tea", and stratifies them according to different frequencies.
At the same time, in order to eliminate interference, three models are created respectively, and the general conditions (age, gender, weight) and biochemical indicators (creatinine, blood sugar, blood lipid) are corrected in turn.
, dietary habits and other possible influencing factors, and finally came to the conclusion that the frequency of drinking "tea" was positively correlated with the risk of hyperuricemia
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At the end of the article, the author also admitted the limitations of this study, including that this study is a single-center cross-sectional study, and although the sample size is large, there is still a possibility of bias; secondly, the data of this study were obtained mainly through the frequency of drinking "tea".
The questionnaire survey did not accurately measure factors such as the content of tea leaves; thirdly, factors that may interfere with uric acid, such as the patient's underlying disease and drug use, were not discussed in this study
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In addition, I think Cantonese people drink "tea".
The concept of "tea" here is more similar to breakfast or even brunch, that is to say, on the basis of drinking tea, it also includes various pastries, animal offal, and soup.
The bottom of the porridge, flour, noodles, etc.
, and these foods have a significant and clear impact on uric acid
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In the future, we look forward to the publication of more excellent research by the research team in the field of Cantonese drinking "tea"
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Based on your clinical experience and the research, what are your suggestions for daily prevention of hyperuricemia? Professor Li Jia Hyperuricemia and gout are lifelong diseases.
As doctors, we should not only fully understand this disease, but also strengthen education and education to patients, so that patients can establish the concept of lifelong treatment, long-term monitoring and regular review
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1.
In terms of diet, low-purine diet, encourage DASH diet, reject Western high-calorie diet, encourage eating more fresh vegetables, fruits, milk, eggs, reject thick broth, animal offal, seafood, soy products are not recommended or recommended , mainly due to the different cooking methods that affect the concentration of uric acid
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It is recommended to drink more water, including boiled water, soda water, and weak tea.
Various beverages, strong tea, and coffee are not recommended, and tobacco and alcohol, especially beer, are not recommended
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2.
In terms of exercise, it is recommended to persevere and progress gradually.
Sufficient water is replenished before and after exercise to prevent the decrease of blood volume due to excessive sweating, the reduction of renal filtration, and the limitation of uric acid excretion through the kidneys, which may induce or aggravate hyperuricemia
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3.
For asymptomatic hyperuricemia, if it is higher than 540 μmol/L, and there are no symptoms including hypertension, hyperglycemia, hyperlipidemia, obesity, coronary heart disease, stroke, cardiac insufficiency, and decreased renal function , gouty nephropathy and other concomitant conditions, uric acid should be controlled within 420 μmol/L; if it is higher than 480 μmol/L, and one of the above complications exists, uric acid should be controlled within 360 μmol/L
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4.
Long-term monitoring of uric acid and urine routine, and regular review at the hospital.
If you take uric acid-lowering drugs, do not stop them easily, because most of the occurrence of gout or the occurrence of refractory gout is based on irregular uric acid-lowering treatment
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Interview with experts Li Jia Director of Endocrinology Department of Southern War Zone General Hospital, MD, postgraduate supervisor Member, Deputy Director of Diabetes Branch of Guangzhou Medical Association, SCI, published more than 40 papers in core journals, edited, participated in editing, and participated in the translation of 5 monographs.
Journal reviewer references: [1] Ruining Li, et al.
Tea Consumption is Associated with an Increased Risk of Hyperuricemia in an Occupational Population in Guangdong, China.
International Journal of General Medicine.
DOI https://doi.
org/ 10.
2147/IJGM.
S355253
.

[2] https://blog.
csdn.
net/weixin_41858481/article/details/95773773.