Drug dependence of codeine phosphate

A few days ago, I saw a guy named Zhu in Xinghua City, Taizhou, Jiangsu Province, who was addicted to cough syrup and spent more than 1 million yuan in three years It's strange, but it's not an accident It's said that another local kid was addicted to the same cough syrup He had no money to buy it, so he had to steal an electric car He has been put into a detention center twice In the Internet age, news is overwhelming, without strong attraction, it will be submerged by massive information in an instant Can you be addicted to drugs? Millions more? People with a little knowledge of pharmacy know that this is not impossible Opium, which was widely used in the Qing Dynasty, was a drug that was harmful to the country and the people But it was once a powerful analgesic, antitussive, antidiarrheal, narcotic, sedative and hypnotic drug, containing more than 30 kinds of alkaloids Because of its addictive nature, it is gradually eliminated Opium poppy shells are added to the hot pot by bad traders It is the use of opioids in them that makes people feel happy, even chronic addiction, and forced to become repeat customers How far is the distance between drugs? The cough syrup in the news above is an oral liquid with the chemical name of compound codeine phosphate Since it's a compound, what are the ingredients in it? It can be found on many websites that 1ml of the solution contains 1mg of codeine phosphate (C18H21NO3? H3PO4? 3 / 2H2O), 0.8mg of ephedrine hydrochloride (C10H15NO? HCl), 0.2mg of Chlorphenamine Maleate (c16h19cln2? C4H4O4) and 22mg of ammonia chloride (NH4Cl) Codeine phosphate has a direct inhibitory effect on the cough center of yannao, and its antitussive effect is strong and rapid It is similar to morphine Besides antitussive effect, it also has analgesic and sedative effects There are many central antitussive drugs, but not all of them are addictive Is this cough medicine addictive? It turns out that codeine phosphate is absorbed rapidly and completely from stomach and intestine after oral administration Codeine, also known as methylmorphine, has a bioavailability of 40% ~ 70% It takes effect 20 minutes and reaches the peak of blood concentration in about one hour It is metabolized by liver and excreted by urine About 10% of codeine is demethylated in vivo to produce morphine, with a half-life of about 3-4 hours Large amount or long-term use is easy to cause dependence, and the tendency of dependence caused by commonly used amount is weaker than other morphine drugs The typical symptoms of dependence are: gooseflesh, anorexia, diarrhea, toothache, nausea and vomiting, runny nose, shivering, sneezing, yawning, sleep disorder, stomach spasm, hyperhidrosis, weakness, heart rate increase, emotional agitation or fever of unknown cause, etc Morphine has a strong analgesic effect and a long time of analgesia The euphoria can relieve the patients' mood So, is codeine phosphate oral liquid can not drink it? It is not necessary to treat the side effects of drugs correctly and talk about the color change of codeine Read the directions of drugs carefully and do not take them in large quantities or for a long time Then you will never be the protagonist in the news of drinking ten or twenty bottles a day.