[dry goods] Guide to selection of microporous filter membrane (praise and forwarding are beneficial)

In the application of membrane separation technology, microporous membrane is a kind of membrane with a wide range of applications Because of its simple and fast use, it is widely used in scientific research, food detection, chemical industry, nanotechnology, energy and environmental protection and many other fields It is very important for protecting the chromatographic system and column to select different kinds of membrane to filter the mobile phase and sample to achieve the function of clearing bacteria and removing impurity particles In this paper, the functions and selection methods of microporous membrane are collected and attached in the form of tables Two kinds of domestic microporous membrane are recommended for selection In addition, if you praise and forward it and leave a message at the end of the article and contact the editor, you will have welfare Recommendation 1: Jiangsu Green League, microporous filter membrane, 100 pieces / bag, special order link: https://store.chembergo.com/goods/pub/detail? Id = 83 Microporous filter membrane includes: mixed cellulose（ MCE, CA, PA / nylon, PP, PES, PVDF, PTFE, PC, glassf I BER) material is mainly used for sample analysis, especially for the filtration of mobile phase and sample in chromatographic analysis, which has a good effect on protecting chromatographic column, infusion pump pipeline system and injection valve from pollution It has been widely used in weight analysis, microanalysis, colloid separation and aseptic experiment Recommendation 2: Tianjin Qimei Φ 50.45 water system / organic system microporous filter membrane order link: https://store.chenbeiango.com/goods/pub/detail? Id = 1226, large air flux, high particle retention rate, good temperature resistance, strong acid, alkali, organic solvent and oxidant resistance, aging and non stick, non flammability and It is non-toxic and biocompatible It is mainly used for filtration of mobile phase and sample in chromatographic analysis It has a good effect on protecting chromatographic column, infusion pump pipe system and injection valve from pollution Materials are divided into organic and inorganic categories In view of the separation characteristics of microfiltration membrane, the application scope of microfiltration membrane is mainly to intercept particles, bacteria and other pollutants from gas phase and liquid phase, so as to achieve the purpose of purification, separation and concentration For microfiltration, the retention characteristics of the membrane are characterized by the pore size of the membrane Generally, the pore size is around 0.1, so the microfiltration membrane can separate large-diameter bacteria, suspended solids, etc It can be used for clarification, security filtration and air sterilization It is widely used in scientific research, medicine and health, biochemistry, food, energy, microelectronics industry, nanotechnology, environmental protection and other departments The following is the introduction of different functions of microporous membrane with different pore size: ① 0.22 μ M: it can remove the extremely fine particles in the sample and mobile phase; it can meet the requirements of 99.99% sterilization specified by GMP or Pharmacopoeia; ② 0.45 μ M: it can filter most bacteria and microorganisms; conventional sample and mobile phase filtration can meet the requirements of general chromatography; ③ 1-5 μ M: filter the impurities of larger particles, or for pretreatment of turbid solution that is difficult to be treated, filter with 1-5 μ M filter membrane first, and then filter with corresponding filter membrane The main function of microporous membrane is to intercept particles, bacteria and other impurities from gas or liquid phase, so as to achieve the purpose of separation, purification and purification Therefore, the following factors should be considered when selecting microporous membrane: ① when selecting microporous membrane material (chemical compatibility), chemical compatibility should be considered first Whether the filter membrane is resistant to acid, alkali, organic solvent, etc Note: (1) r (resistant) indicates that it can tolerate this chemical reagent; (2) LR (limited resistance) indicates that it can tolerate this chemical reagent; (3) NR (not resistant) indicates that it cannot tolerate this chemical reagent; (2) pore diameter of microporous filter membrane of filter membrane shall be 0.45 μ m for conventional sample mobile phase filtration, which can meet general chromatographic requirements, For example, it is used in the chromatographic system of 3 μ m or larger particle size packing 0.22 μ M can remove the requirement of very fine particles in the sample and mobile phase, such as: for chromatographic system with < 3 μ m filling angle 1-5pm is often used for the turbid solution which is difficult to be treated It can be pre filtered with 1-5pm filter membrane first, and then filtered with corresponding filter membrane ③ Characteristics of samples characteristics of samples hydrophilic samples of microfiltration membrane selected hydrophilic membrane It has affinity for water and is suitable for filtering water based solutions The available filter membranes are: water system membrane (mixed fiber rope ester) and nylon membrane (polyamide) Organic and inorganic compounds (alcohols, esters, oils) samples are suitable for nylon film strong corrosive organic solvents generally hydrophobic film Such as ptfem, polypropylene (PPM) and other materials For protein solution, select filter membrane with low protein adsorption, such as PVDF filter membrane It is generally considered that PES membrane is suitable for filtration of solution with low inorganic ions Hydrophobic PTFE (polytetrafluoroethylene membrane) for strong acid and strong base samples Characteristics of several commonly used filter membranes materials characteristics of microporous filter membranes nylon membranes (nylon) It has good temperature resistance, can withstand 121 ℃ saturated steam pressure sterilization for 30min, the maximum working temperature is 60 ℃, chemical stability is good, and can withstand dilute acid, dilute alkali, alcohol, ester, oil, hydrocarbon, halohydrocarbon, organic oxide and other organic and inorganic compounds Electronic, microelectronic, semiconductor industrial water filtration, tissue culture medium filtration Liquid medicine filtration, beverage filtration, high-purity chemicals filtration; filtration of aqueous solution and organic mobile phase filtration Polyvinylidene fluoride (PVDF) membrane has high mechanical strength, high tensile strength, good heat resistance and chemical stability, low protein adsorption rate, strong negative electrostatic and hydrophobicity, hydrophobic and hydrophilic forms But it can not tolerate acetone, DMSO, THF, DMF, dichloromethane, chloroform, etc Hydrophobic polyvinylidene fluoride membrane is mainly used for gas and steam filtration and high-temperature liquid filtration; hydrophilic polyvinylidene fluoride membrane is mainly used for purification and filtration of sterilization and filtration solvent and chemical raw materials such as tissue culture medium and additives, aseptic treatment of reagents, filtration of high-temperature liquid, etc Mixed cellulose ester (MCE) has uniform pore size, high porosity, no medium shedding, thin texture, small resistance, fast filtration speed, minimal adsorption, low cost of use, but it is not resistant to organic solutions and strong acid and alkali solutions In the pharmaceutical industry, it is necessary to use hot pressure sterilized water injection and large infusion to remove particles; for the sterilization of heat sensitive drugs (insulin ATP, coenzyme A and other biochemical agents), it is necessary to use 0.45 μ M filter membrane (or 0.2); for the analysis and determination of particles and oil insoluble substances in solution, and for the determination of water pollution index; for the research departments such as somatic hybridization and line particle complementary prediction of heterosis Polypropylene (PPM) is free of any adhesive Its chemical properties are stable, flexible, not easy to be damaged, high temperature resistant, and can withstand high pressure sterilization It is poisonous, tasteless, acid and alkali resistant It is suitable for making all kinds of coarse and fine filters and folding filter elements; it is suitable for plate and frame filter press membrane in beverage, medicine and other industries; it is suitable for supporting and pretreatment of reverse osmosis membrane and ultrafiltration membrane; polypropylene membrane is non-toxic and can be widely used in medicine, chemical industry, food, beverage and other fields; it has hydrophobicity and is especially good for gas filtration Polyethersulfone (PES) is a kind of hydrophilic membrane, which has the characteristics of high flow rate, low dissolution and good strength It does not adsorb protein and extract and pollutes sample 5 Low protein adsorption and high drug compatibility, specially designed for biochemical, inspection, pharmaceutical and sterilization filtration devices Polytetrafluoroethylene (PTFE) has the most extensive chemical compatibility, and can withstand DMSO, THF, DMF, dichloromethane, chloroform and other strong solvents The filtration of all organic solutions, especially the filtration of strong solvents that cannot be tolerated by other membranes Quick selection table of filter membrane: solution solution and water filtration CNM, nylonm, cam, MCEM tissue culture medium nylonm, hydrophilic pvdfm, PESM solution filtration, beverage filtration nylonm, PESM General Microbiology CNM reagent aseptic treatment hydrophilic pvdfm Determination of water quality pollution index, sterilization and microparticle analysis of MCEM drugs, filtration of biology and serum in MCEM pharmaceutical industry, terminal filtration of large infusion, antibacterial, etc PESM conventional filtration, low protein adsorption, ultra pure water terminal filtration, cam, pvdfm, PESM alcohol solution, PESM mixture, can ion chromatography Nylon m, ptfem solvent soluble non-polar (hydrophobic) PESM polar (hydrophilic) ptfem strong corrosive organic solvent nylon m, hydrophilic pvdfm gas air ptfem, PPM vacuum pump exhaust ppm, ptfem, MCEM gas and steam filtration nylon M Filtration of high temperature liquid pvdfm, filtration of ptfeh compressed liquid pvdfm, sterilization and filtration of ptfem compressed air pvdfm, precautions for ptfem to use mixed cellulose ester microporous filter membrane: 1 Accurately select the pore size of the filter membrane, that is, the filter residue is larger than the pore size of the filter membrane 2 The filter membrane needs to be rinsed with distilled water twice and soaked for 4 hours before use 3 If there are many particles and bacteria in the filtrate, it should be pre filtered first to avoid the filter membrane blocking too fast 4 Most of the filter membranes can be sterilized by hot pressing, boiling or chemical disinfection 5 Air tightness and air bubble shall be tested before and after use 6 When filtering the liquid, the filter membrane must be wetted If the filter membrane is dried due to hot pressure disinfection, it can only be used after being wetted with sterile water 7 Through toxicity test, the mixed fiber membrane is non-toxic and can be used in medicine, food and other industries 8 Hydrophobic membrane, acid resistant membrane and solvent resistant membrane are required for gas filtration, which can be customized by contacting the manufacturer 9 It is generally applicable to ph4-8 solution 10 The storage condition is better when the relative temperature is 60% In order to ensure the quality, it should not be stored for a long time The purpose of microporous membrane is to filter out the particles and bacteria in water solution, oil and gas filtration, and to detect the particles and bacteria in quality control It is widely used in pharmaceutical, chemical, pharmaceutical, hospital, scientific research, bioengineering and chromatography membrane 1 Pharmaceutical industry: filter particles in water injection and large infusion that need hot pressing sterilization to improve the qualification rate of clarity and particle detection Sterilization and filtration of heat sensitive drugs such as insulin A, t, P biological and blood preparations 2 Food industry: alcohol, beverage, mineral water, etc filter yeast bacteria, etc 3 Medical and health care: analyze the binding of c-AMP RNA and DNA by the special adsorption performance of membrane to protein 4 Mechanochemistry: Airborne kerosene, internal combustion engine oil and other gravimetric particle detection 5 Electronic industry: high purity water filtration, MOS pure reagent, acid-base filtration Welfare: definition, characteristics and application precautions of filter membrane and microporous filter membrane