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Macrophages play a key role in shaping the tumor microenvironment, tumor immunity, and response to immunotherapy.
At the same time, they are also an important target for the development of new cancer therapies; however, it is very difficult to regulate macrophages because current researchers Lack of understanding of the molecular and functional diversity of tumor macrophages.
Macrophages are produced in two different lineages.
Macrophages residing in tissues can self-renew locally and are not dependent on the adult hematopoietic process.
The short-lived monocyte-derived macrophages are derived from adult hematopoietic stem cells, which are mainly concentrated in inflammatory lesions.
At present, researchers do not know how these macrophage lineages promote the tumor microenvironment and cancer progression
Recently, in a research report titled "Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells" published in the international journal Nature, scientists from the Icahn School of Medicine on Mount Sinai found that when When cancer begins to form in the lung tissues, the immune cells used to repair the body's tissues will be "fooled" by the tumor, which in turn helps the tumor to become more aggressive
Researchers have discovered that early lung cancer tumors cooperate with immune cells called tissue-resident macrophages to help invade lung tissue; in addition, they have also drawn a map to reveal how macrophages make In the case of tumor damage, macrophages can repair the tissue.
This process can promote the tumor to avoid the host's immune system and continue to proliferate until it progresses to the lethal stage of cancer
Macrophages play a key role in shaping the tumor microenvironment.
The tumor microenvironment is the ecosystem around the tumor in the body.
By investigating this microenvironment, researchers can find the key "players" that drive tumor growth.
It may be tested as a target of immunotherapy, but it turns out that therapeutic modification of macrophages is very difficult
In this study, researchers studied lung cancer tumors and surrounding lung tissue samples from 35 patients, revealing the key role macrophages play in tumorigenesis
Miriam Merad, MD, said that we designed a comprehensive study that starts from the patient entering the operating room to remove the cancer lesions, and then analyzes the patient’s lung tumor samples, samples around healthy lung tissue, and blood samples at the cellular level.
, So as to draw a map of the immune system components it contains
Researchers have identified the key role that macrophages play in the early occurrence of lung cancer, which may be used as a new potential target for the development of new drug therapies in the future; in addition, this process can also allow macrophages to help tumors invade the lungs Organization, this phenomenon also exists in mice, which may allow researchers to manipulate macrophages in mouse models
It turns out that half of all early-stage lung cancers will recur.
Once they recur and enter the later stages, they can become very deadly.
To clarify how to attack cancer at the early stage may be useful for developing new therapies for the treatment of many cancer patients.
Improving their overall survival is crucial
Researcher Merad said that the results of this article are crucial for researchers to develop a new type of lung cancer screening project.
This project may be able to identify early-stage lung cancer patients before the patient’s cancer cells are completely invaded, and the relevant research results can also be passed.
Reprogramming macrophages and killing cancer cells without surgery has helped scientists design immune prevention strategies to prevent tumor progression in patients at risk
In summary, in this study, the researchers identified the contribution of tissue-resident macrophages to the occurrence of early lung cancer, and at the same time established that they may be used as a new target to help develop new preventive and therapeutic properties for early lung cancer.
, Dalla, E.
, Leader, AM et al.
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.