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Macrophages play a key role in shaping the tumor microenvironment, tumor immunity, and response to immunotherapy.
Researchers have discovered that early lung cancer tumors cooperate with immune cells called tissue-resident macrophages to help invade lung tissue; in addition, they have also drawn a map to reveal how macrophages make In the case of tumor damage, macrophages can repair the tissue.
In this study, researchers studied lung cancer tumors and surrounding lung tissue samples from 35 patients, revealing the key role macrophages play in tumorigenesis
Researchers have identified the key role that macrophages play in the early occurrence of lung cancer, which may be used as a new potential target for the development of new drug therapies in the future; in addition, this process can also allow macrophages to help tumors invade the lungs Organization, this phenomenon also exists in mice, which may allow researchers to manipulate macrophages in mouse models
Researcher Merad said that the results of this article are crucial for researchers to develop a new type of lung cancer screening project.
Original source:
Casanova-Acebes, M.