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According to the latest global cancer data for 2020 released by the World Health Organization, colorectal cancer (CRC) has become the third largest cancer in the world, and the age of patients is gradually getting younger.
Combined with the sharp increase in the intake of sugary beverages (SSB) such as fruit juices and sodas and meat in recent decades, the high-fat and high-sugar diet is considered to be one of the reasons for the increase in the incidence of CRC.
Studies have shown that high sugar intake can promote colorectal cancer by causing insulin resistance, obesity and type 2 diabetes (a known risk factor for CRC).
However, most prospective studies have reported that there is no significant association between adult sugar intake and colorectal tumors.
Considering that adolescence has a physiological decrease in insulin sensitivity and a surge in insulin-like growth factor 1 (IGF1), it may be a critical period of increased susceptibility to the adverse effects of high sugar intake, which will affect the early occurrence of CRC.
Recently, researchers from the Harvard School of Public Health in the United States and the Seoul National University School of Medicine in South Korea published a study titled Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors in Gastroenterology, and found that adolescence has a large amount of Intake of high-sugar foods and SSB will significantly increase the risk of conventional adenomas and high-risk adenomas, especially rectal adenomas.
DOI: https://doi.
org/10.
1053/j.
gastro.
2021.
03.
028 In order to explore whether adolescent sugar intake affects the risk of CRC, the researchers analyzed the prospective study cohort-Nurse Health Study that began in 1989 The 33,106 female participants in the NHSII (NHSII) conducted a survey and analysis, and counted the types of food consumed by the participants during adolescence (13 to 18 years old), including fruit juice, SSB, and artificial sweetened beverages (ASB).
Dosage, and regularly ask participants whether they have undergone enteroscopy and their diagnosis.
In addition, the researchers also counted the participants’ adolescence and current BMI, smoking, drinking, diabetes and other chronic medical history, aspirin taking history and other covariate information.
The results of the dietary survey of the participants showed that 12.
6% and 4.
8% of the participants had at least one serving and two servings of SSB per day during adolescence, and their fructose and SSB intakes accounted for an average of 2.
6% of daily calories.
Significantly higher than the adult participants, and those with higher SSB intake prefer to eat red meat, and consume less fruits and vegetables.
During the follow-up period, a total of 4744 women were diagnosed with at least one colorectal polyp, of which 2909 participants had adenomas (1548 proximal, 1205 distal, 458 rectal and 758 high-risk adenomas).
2355 participants were found to have serrated lesions.
After adjusting the covariate information, the logarithmic regression model was used to analyze the correlation between sugar and SSB intake and the risk of CRC, and it was found that the increase in total fructose intake during adolescence was significantly positively correlated with the risk of adenoma.
Fructose intake Each increase of 5% calories/day in intake will increase the risk of total adenoma and high-risk adenoma by 17% and 30%, respectively.
However, fructose intake was not significantly related to serrated lesions.
The risk ratio and 95% confidence interval of total fructose intake and colorectal polyps.
In addition, the researchers also found that higher SSB intake in adolescents was also significantly associated with higher risk of rectal adenomas, but not with serrated lesions.
Each increase in SSB intake by 1 serving per day increases the risk of high-risk adenomas in the rectum by 34%.
There is no correlation between the adult consequences of sugar and SSB intake and high-risk adenomas.
The hazard ratio and 95% confidence interval of the intake of sugar-sweetened beverages and colorectal polyps and the 95% confidence interval of the intake of fructose and sugar-sweetened beverages and the hazard ratios and 95% confidence intervals of the intake of fructose and sugar-sweetened beverages and low-risk and high-risk colorectal adenomas and 95% confidence intervals If the predecessor of the disease is not controlled, it will evolve into colorectal cancer.
Whether considering weight loss or physical health, we should reduce the intake of sugar as much as possible within a reasonable range, especially sugary drinks! End reference materials: [1]
Combined with the sharp increase in the intake of sugary beverages (SSB) such as fruit juices and sodas and meat in recent decades, the high-fat and high-sugar diet is considered to be one of the reasons for the increase in the incidence of CRC.
Studies have shown that high sugar intake can promote colorectal cancer by causing insulin resistance, obesity and type 2 diabetes (a known risk factor for CRC).
However, most prospective studies have reported that there is no significant association between adult sugar intake and colorectal tumors.
Considering that adolescence has a physiological decrease in insulin sensitivity and a surge in insulin-like growth factor 1 (IGF1), it may be a critical period of increased susceptibility to the adverse effects of high sugar intake, which will affect the early occurrence of CRC.
Recently, researchers from the Harvard School of Public Health in the United States and the Seoul National University School of Medicine in South Korea published a study titled Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors in Gastroenterology, and found that adolescence has a large amount of Intake of high-sugar foods and SSB will significantly increase the risk of conventional adenomas and high-risk adenomas, especially rectal adenomas.
DOI: https://doi.
org/10.
1053/j.
gastro.
2021.
03.
028 In order to explore whether adolescent sugar intake affects the risk of CRC, the researchers analyzed the prospective study cohort-Nurse Health Study that began in 1989 The 33,106 female participants in the NHSII (NHSII) conducted a survey and analysis, and counted the types of food consumed by the participants during adolescence (13 to 18 years old), including fruit juice, SSB, and artificial sweetened beverages (ASB).
Dosage, and regularly ask participants whether they have undergone enteroscopy and their diagnosis.
In addition, the researchers also counted the participants’ adolescence and current BMI, smoking, drinking, diabetes and other chronic medical history, aspirin taking history and other covariate information.
The results of the dietary survey of the participants showed that 12.
6% and 4.
8% of the participants had at least one serving and two servings of SSB per day during adolescence, and their fructose and SSB intakes accounted for an average of 2.
6% of daily calories.
Significantly higher than the adult participants, and those with higher SSB intake prefer to eat red meat, and consume less fruits and vegetables.
During the follow-up period, a total of 4744 women were diagnosed with at least one colorectal polyp, of which 2909 participants had adenomas (1548 proximal, 1205 distal, 458 rectal and 758 high-risk adenomas).
2355 participants were found to have serrated lesions.
After adjusting the covariate information, the logarithmic regression model was used to analyze the correlation between sugar and SSB intake and the risk of CRC, and it was found that the increase in total fructose intake during adolescence was significantly positively correlated with the risk of adenoma.
Fructose intake Each increase of 5% calories/day in intake will increase the risk of total adenoma and high-risk adenoma by 17% and 30%, respectively.
However, fructose intake was not significantly related to serrated lesions.
The risk ratio and 95% confidence interval of total fructose intake and colorectal polyps.
In addition, the researchers also found that higher SSB intake in adolescents was also significantly associated with higher risk of rectal adenomas, but not with serrated lesions.
Each increase in SSB intake by 1 serving per day increases the risk of high-risk adenomas in the rectum by 34%.
There is no correlation between the adult consequences of sugar and SSB intake and high-risk adenomas.
The hazard ratio and 95% confidence interval of the intake of sugar-sweetened beverages and colorectal polyps and the 95% confidence interval of the intake of fructose and sugar-sweetened beverages and the hazard ratios and 95% confidence intervals of the intake of fructose and sugar-sweetened beverages and low-risk and high-risk colorectal adenomas and 95% confidence intervals If the predecessor of the disease is not controlled, it will evolve into colorectal cancer.
Whether considering weight loss or physical health, we should reduce the intake of sugar as much as possible within a reasonable range, especially sugary drinks! End reference materials: [1]
