Eat out the "fourth highest", uric acid "cross the border" has these signs

Original title: eat out of the "fourth high", uric acid "crossing the border" has these signs
high blood pressure, high blood lipids, high blood sugar "three high" said that many people have been familiar with. In recent years, with the popularity of physical examination, "high uric acid" gradually into people's vision, in the middle-aged and elderly "high uric acid" a number of people, so some people call it after the "three high" the fourth high.
blood pressure, blood lipids, blood sugar is not difficult to understand, what is this uric acid? Uric acid, as the name implies, should be excreted in the urine, but the level of uric acid is not the result of urine testing, but the result of blood tests, that is, high uric acid content in the blood, the correct statement should be "blood uric acid increase." How does uric acid increase in the blood?
All organisms, including, of course, the human body, are made up of cells and their products, cells have nucleic or similar nucleic structures, including nucleic acids, RNA or DNA, nucleic acids consisting of two types of nucleotides and phosphoric acids. The body's cells are constantly metabolized, food is digested, absorbed, decomposed, the nucleotides in the nucleosclea eventually decomposed into ammonia and carbon dioxide, and the nirconium nucleotides evolved into uric acid. Therefore, it can be known that the uric acid in the blood comes from the body's own metabolism and food, the former is called endo endo-uric acid, the latter is exo-uric acid.
usually contains about 1200 milligrams of uric acid in human blood, of which endo endo-uric acid accounts for about 80%. These uric acids are constantly updated, producing about 750 mg per day and excreting 500 to 1000 mg to form a rough balance. It is not difficult to understand that uric acid in the blood increases if too much or too little is excreted. Too much is found in fever, vigorous exercise, trauma, surgery, radiation chemotherapy for cancer patients, severe expendable diseases, and short-term intake of foods rich in nirconium nucleotides, which can be seen in kidney disease or urinary tract obstruction or inability to produce sufficient amounts of urine due to dehydration.
However, the chemical composition of cells is protein, its metabolism is not isolated, but a part of the body's metabolism, and fat metabolism, sugar metabolism is closely related, and subject to genetic factors. So many people don't seem to have these obvious causes of increased blood uric acid, but they also have increased blood urine. Experts believe that this "higher blood uric acid" is really the "three high" of the same party, metabolic syndrome (obesity and hypertension, hyperlipidemia, diabetes and other conditions that occur in the same body at the same time or successively).
the concentration of uric acid in the blood exceeds its saturation, it may theoretically be folded out in the form of crystallization, but the uric acid crystallization is also related to local blood circulation, body temperature, pressure and other factors, so deposited in the joints, especially large feet Toe and othertoe joints and other parts, or deposited in the kidney myelin, kidney nipples and other parts, because such crystallization is a foreign body, and then triggered the human body to reject foreign body inflammatory response, that is, gout arthritis, gout nephropathy. Uric acid crystallization is deposited in the renal collection tube, kidney, ureter and even directly hinder the excretion of urine, leading to acute renal failure. The incidence of urinary stones in such patients is as high as 35% to 40%, 200 times higher than in normal people.
blood uric acid as a disease state, its official name should be "high uric acidemia." In the past, the understanding of the harm of high uric acidemia was more than to cause gyroarthritis and gyrophic nephropathy. Because the risk of gout arthritis in patients with increased blood uric acid is only 5% to 12%, gout kidney disease in the early stages are also more hidden, so the increase in uric acid is easy to be ignored. However, recent studies have confirmed that uric acid and uric acid crystallization in the blood of people with hyperureticemia can also damage endotrine cells of arterial blood vessels, while damage to the endotrine of arteries can cause and aggravate atherosclerosis, leading to cardiovascular disease, so hyperureticemia is considered to be an independent risk factor for cardiovascular disease. The so-called independent, that is, without the need for other supporting factors, this alone can cause cardiovascular disease risk. Uric acid and uric acid crystallization in the blood of people with hyperureticemia can also damage the β cause diabetes. The study found that for every 60 micromole/litre increase in uric acid, the risk of hypertension increased by 15% to 23% and the risk of diabetes by 17%. People with high uric acidemia had a 47 percent increased risk of stroke compared to the normal population.
Uric acid and triglycerides are often accompanied by increased, in hyperlipidemia 60% to 80% combined hyperureticemia, in hypertension 90% combined with hyperureticemia, so this "hyperureticemia" as part of metabolic syndrome is beyond doubt. The normal value of blood uric acid before menopause is less than 360 micromolars / liter, after menopausal women and men are less than 420 micromole / liter, if exceeded this value is "blood uric acid increase." Most people with elevated blood uric acid are asymptomatic, but should never be taken lightly, one is to check the cause of elevated blood uric acid, if there are specific reasons should be tried to correct. Second, blood pressure, blood lipids, blood sugar and obesity should be checked, if there are abnormalities should also be tried to correct.
High uric acidemia can be treated with drugs, commonly used drugs have inhibited uric acid production, have to promote uric acid excretion, should be used by doctors in accordance with the prescription of the disease, gout attacks often need to be applied to inhibit the inflammatory response of drug therapy.
question is whether the majority of asymptomatic blood uric acid increase should be confirmed as uric acid increase should start medication? From the rationale, high uric acidemia is not only an independent risk factor of cardiovascular disease, it should be treated to eliminate the risk of cardiovascular disease. However, there is insufficient (evidence-based medicine) evidence to prove that medication for asymptomatic high uric acidemia can actually reduce the risk of cardiovascular disease. Therefore, it is generally advocated that the blood uric acid is higher than normal (420 micromolars / liter) but less than 480 micromolars / liters do not use drug treatment, for blood uric acid in 480 micromolars / liter to 540 micromolars / liter, if asymptomatic but Those who have kidney damage or have developed adverse cardiovascular conditions should begin to take medication for uric acid, while those with or above 540 micromolars/litre of uric acid, whether symptomatic or damage to the heart, kidneys, joints, etc., advocate the use of uric acid-lowering drugs.
should be treated with medication and what kind of medication should be followed. For those with increased blood uric acid, the key is to focus on their own life behavior: endoen endouric uric acid or difficult, but eat as little as possible high nucleotide content of foods such as seafood (especially shellfish seafood), red meat (cow and sheep pork), animal offal, repeatedly cooked broth (old soup hot pot) and vegetables in asparagus, spinach, zucchini, peas and so on. Sugary (mainly fructose, sucrose and other monosaccharides, double-sugar structure of sugars) foods, especially apples, grapes, watermelons and fructose-rich beverages (juices) in fruit, can promote nirconium nucleotides when metabolized in the liver Degradation, increase the formation of uric acid, alcohol (especially spirits) may also have this effect, alcohol and fructose drinks can also reduce uric acid excretion is certain, blood uric acid increase is not suitable for consumption. Conversely, skimmed milk and coffee have the effect of promoting uric acid excretion and can be drunk as appropriate. Soybeans and soy products have also been regarded as dietary taboos by those with high blood uric acid because of the high content of radon in soybeans in the past. However, in recent years, it has been pointed out that soy products in the processing process of nirconium nucleotides have been a large number of losses, even if directly eat soybeans, blood uric acid is not significantly increased, it is possible that such substances in soybeans are not easy to be absorbed, there is no longer a strong tone on the blood uric acid increasers taboo such foods. Some drugs such as cyclocytocin, pyrithrin, small doses of aspirin, etc. have the effect of inhibiting uric acid excretion, but the drug is used for the treatment of diseases, the selection should be decided by the physician. People with high uric acidemia should drink more water, so that the daily urine volume of more than 2000 ml, to promote uric acid excretion, is also very important.
adjustment of life behavior is the basis of the treatment of high uric acidemia, whether symptomatic or not, whether or not the use of medication should be the case, and should be persistent. The physical examination found that the blood uric acid increased and should be paid full attention to.
this paper by Fudan University affiliated Zhongshan Hospital Chief Physician Yang Binghui scientific control.
the "Da Medical Care" contribution