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    Home > Active Ingredient News > Infection > EBioMedicine: Novel coronavirus mRNA vaccine induces higher antibody affinity and IgG titers against related variants compared with non-postpartum women

    EBioMedicine: Novel coronavirus mRNA vaccine induces higher antibody affinity and IgG titers against related variants compared with non-postpartum women

    • Last Update: 2022-05-16
    • Source: Internet
    • Author: User
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    Background: The rapid emergence of novel coronavirus volatile organic compounds worldwide is associated with varying levels of resistance to neutralization in convalescent plasma, neutralizing monoclonal antibodies, and post-vaccination serum


    Background: The rapid emergence of novel coronavirus volatile organic compounds worldwide is associated with varying levels of resistance to neutralization in convalescent plasma, neutralizing monoclonal antibodies, and post-vaccination serum


    During the evaluation of the SARS-COV-2 vaccine, pregnant and breastfeeding women were not included in some large-scale clinical trials


    In the current study, we performed a longitudinal quantitative and qualitative analysis of mRNA vaccine-induced antibody responses in postpartum lactating versus non-postpartum lactating women to identify any potential differences in RBD-binding antibodies and neutralize cross-nCoV variability body effectiveness


    Methods: We elucidate the antibody profile induced by longitudinal mRNA vaccination in 13 postpartum and 13 non-postpartum women (control group)


    RESULTS: Antibody neutralization titers against the 2019-nCoV WA-1 strain were comparable in postpartum and non-postpartum women, and in both groups, these levels persisted up to 4 months after the second vaccination


    Figure 1 Antibody titers against various novel coronavirus strains in plasma or breast milk following vaccination in neutralizing postpartum and non-postpartum women


    Figure 1 Antibody titers against various novel coronavirus strains in plasma or breast milk following vaccination in neutralizing postpartum and non-postpartum women


    Figure 2 Binding antibodies to the vaccine-cognate 2019-nCoV receptor binding domain and its mutants in plasma or breast milk after mRNA vaccination of postpartum and non-postpartum women


    Figure 2 Binding antibodies to the vaccine-cognate 2019-nCoV receptor binding domain and its mutants in plasma or breast milk after mRNA vaccination of postpartum and non-postpartum women


    Figure 3


    Figure 3


    Conclusions: This study demonstrates that postpartum women experience different vaccination-induced immune responses compared to non-postpartum women, which may help inform future vaccination strategies in these groups


    Original source: Lee Y, Grubbs G, Ramelli SC, et al.
    SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women .
    EBioMedicine 2022 Mar;77 SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women

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