eClinicalMedicine: The team of Prof. Zixiao Li/Yongjun Wang proposed an accurate phenotype of ischemic stroke

In September 2022, the team of Professors Li Zixiao and Wang Yongjun of the Neurology Center of Beijing Tiantan Hospital affiliated to Capital Medical University published a report entitled "Data-driven clustering approach to identify novel phenotypes using multiple biomarkers in acute ischaemic" in the international journal eClinicalMedicine stroke: a retrospective, multicentre cohort study" research paper

Based on the big data-driven first comprehensive and systematic analysis of patients with acute ischemic stroke, this study proposes a new biomarker-based precise phenotype of acute ischemic stroke, realizes accurate risk stratification of stroke population, reveals the pathophysiology mechanism related to AIS poor prognosis, and lays a foundation

Acute ischemic stroke (AIS) is a major disease that seriously threatens human health and life, and has become one of the leading causes of

In order to answer the above important clinical questions, the team of Prof Li Zixiao and Prof.

This study applies machine learning methods to find reliable biomarkers in the national stroke cohort, and for the first time exploratorically constructs an accurate phenotype of acute ischemic stroke using biomarkers, which is conducive to further understanding the pathophysiology mechanism of the occurrence and development of ischemic stroke and providing direction

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The research was funded by the Key Research Project of Beijing Natural Science Foundation (Z200016), the Special Project of Pharmaceutical Collaborative Science and Technology Innovation of Beijing Municipal Science and Technology Commission (Z201100005620010), the National Natural Science Foundation of China (82101360, 92046016, 82171270), the Medical and Health Science and Technology Innovation Engineering Project of the Chinese Academy of Medical Sciences (2019-I2M-5-029) and the Stroke Precision Clinical Diagnosis and Treatment and Research Center of Capital Medical University

Wang Yongjun

Professor of Neurology, Chief Physician, Doctoral Supervisor, President of Beijing Tiantan Hospital affiliated to Capital Medical University, Director of the National Medical Quality Control Center for Neurological Diseases, Deputy Director of the National Clinical Research Center for Neurological Diseases, Director of the Beijing Brain Protection High-Precision Innovation Center, Chairman of the Neurology Branch of the Chinese Medical Association, and Editor-in-Chief

Li Zixiao

Professor of Neurology, Chief Physician, Doctoral Supervisor, Deputy Director