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Recently, the Environmental and Health Research Center of Chongqing Institute of Green Intelligence Technology of the Chinese Academy of Sciences, in cooperation with the Center for Microna Manufacturing and Systems Integration Research and the School of Materials Science and Engineering of Zhengzhou University, used zebrafish models to further study the perturbation of graphene quantum dots on the AHR signal path of zebrafish and made new progress.
graphene quantum dot has been widely used in medicine and biofluorescence imaging.
, however, the biological properties inherent in graphene quantum dots and the potential risks in biological systems are still unknown.
team successfully synthesized reductive graphene quantum dots (rGOQDs) with quantum yields of up to 24.62% using improved Humers methods and DMF hydrothermal treatment methods.
fluorescent bioimaging after exposure to zebrafish using different concentrations of rGOQDs, and the distribution of rGOQDs in zebrafish was successfully observed.
addition, the team assessed the developmental and genotoxicity of rGOQDs to zebrafish to further study the potential biological harm of rGOQD.
results show that rGOQDs have some effect on zebrafish development, malformation rate and rGOQDs have concentration dependence, and genetically modified zebrafish Tg (cyp1a:gfp) was used to study its disturbance to aromatics-dependent path.
results showed that rGOQD significantly increased the expression of green fluorescent protein (GFP) of genetically modified zebrafish Tg (cyp1a:gfp), which was further confirmed by Western blot.
research provides a valuable reference for the interference study of graphene materials in the ahR signal path of organisms.
the above-mentioned research results have been the Chongqing Science and Technology Commission application and development of major projects (cstc2014ykfC20004), the Chinese Academy of Sciences "100-person plan", western light and other related projects funded.
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