Effects of polymorphism of enteritis-sensitive genes on intestinal bacteria and Crohn's disease.

Intestinal bacteria play an important role in human health.
recent years, research on intestinal bacteria has increasingly become the focus of interest to scientists.
the exploration of the complex mechanism of
symbient-mutual benefit" will be of great significance to the study of the pathogenesis of diseases caused by abnormal intestinal bacteripora, as hosts and intestinal bacteri in the long-term evolutionary process interact to regulate the environmental stability of the intestines.
crohn's disease is a major disease that endangers human health.
the cause and pathogenesis of the disease are still not very clear.
, more and more studies have shown significant changes in the gut microbiotics of crohn's disease, which play an important role in the pathogenesis of Crohn's disease.
Fuping of the Institute of Microbiology of the Chinese Academy of Sciences focused on the effects of polymorphisms of enteritis-sensitive genes on intestinal bacteria and Crohn's disease.
Using mouse models of pathogenic bacteria infected with enteritis-induced genes, it was found that the effect of pathogenic bacterial infections on mice was more pronounced than in the wild, with a stronger manifestation of inflammatory bowel disease (including Crohn's disease), indicating that mutations in this sensitive gene led to the destruction of the balance of the intestinal bacteribus in the host and a change in the stability of the intestinal environment.
next step will focus on the key role of intestinal bacteriologic groups in the onset of Crohn's disease and the specific mechanisms that regulate the immune response, which is of great significance for promoting personalized treatment of Crohn's disease.
The results were recently published online in the journal Journal of Immunology, with Gao Ping, an assistant researcher with Zhang Fuping's research team, as the first author of the article, and graduate students Liu Hongtao and Huang Huaxuan, who were also involved, and Zhang Fuping, who was the author of the communication.
the study was funded by the National Natural Science Foundation of China (31300719 and 31470861) and the National Key Research and Development Program (2016YFC1200302).
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