Efficacy and mechanism of Nutrients sweet tea in preventing ulcerative colitis in mice

Recently, the research and innovation team of plant and human health medical mechanism research and innovation team from the Urban Agriculture Research Institute of the Chinese Academy of Agricultural Sciences, together with researchers from Chengdu University, Sun Yat-Sen University, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital Laboratory Animal Research Institute and other researchers, published a report in the international medical journal Nutrients (JCR District

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This research was supported by the National Agricultural Science and Technology Center Chengdu Local Financial Funding Project (.

01 Article overview

In recent years, natural plant bioactive compounds, such as polyphenols and flavonoids, have received increasing attention in preventing UC injury due to their strong anti-inflammatory capacity and safety advantag.

In conclusion, sweet tea ethanol extract has a good anti-colitis effect, and the underlying mechanism may be related to the regulation of gut microbiota to activate butyrate-GPRs (GPR43 and GPR109A) anti-inflammatory signaling cascade, while inhibiting HDAC3/NF-κB activation of inflammatory signaling pathwa.