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    Home > Biochemistry News > Biotechnology News > Electrochemical Detection of 8-Hydroxy-2-Deoxyguanosine Levels in Cellular DNA

    Electrochemical Detection of 8-Hydroxy-2-Deoxyguanosine Levels in Cellular DNA

    • Last Update: 2021-02-24
    • Source: Internet
    • Author: User
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    Oxidative stress has been implicated in the etiology of many pathological states and known to result in
    damage. Oxidative DNA damage can lead to mutagenesis (

    ) and has been associated with aging (
    ), diabetes mellitus (
    ), inflammatory disease (
    ) and carcinogenesis (

    ). The 8-hydroxy-2-deoxyguanosine lesion (8-OHdG) is often used in the assessment of oxidative DNA damage and has become the de facto marker for oxidative damage to DNA. 8-OHdG is one of the most prominent lesions observed following exposure to ionizing radiation (
    ) but also results from treatment with many xenobiotics (
    ) as well as by endogenous mechanisms. Thus, normal endogenous levels becomes a critical issue in the assessment of cellular 8-OHdG levels in pathological states. Furthermore, 8-OHdG is efficiently repaired by a DNA glycosylase specific for this lesion (
    ) and its contribution to mutagenesis is relatively weak (

    ). However, it is representative of approximately 20 additional oxidatively-denved lesions known to result from radiation damage (
    ) and whose mutagenic outcome are largely unknown in mammalian-cell systems.
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