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    Home > Biochemistry News > Biotechnology News > Electrochemical Detection of 8-Hydroxy-2-Deoxyguanosine Levels in Cellular DNA

    Electrochemical Detection of 8-Hydroxy-2-Deoxyguanosine Levels in Cellular DNA

    • Last Update: 2021-02-24
    • Source: Internet
    • Author: User
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    Oxidative stress has been implicated in the etiology of many pathological states and known to result in
    DNA
    damage. Oxidative DNA damage can lead to mutagenesis (
    1

    3
    ) and has been associated with aging (
    4
    ), diabetes mellitus (
    5
    ), inflammatory disease (
    1
    ) and carcinogenesis (
    1

    3
    ,
    6
    ). The 8-hydroxy-2-deoxyguanosine lesion (8-OHdG) is often used in the assessment of oxidative DNA damage and has become the de facto marker for oxidative damage to DNA. 8-OHdG is one of the most prominent lesions observed following exposure to ionizing radiation (
    7
    ) but also results from treatment with many xenobiotics (
    8
    ) as well as by endogenous mechanisms. Thus, normal endogenous levels becomes a critical issue in the assessment of cellular 8-OHdG levels in pathological states. Furthermore, 8-OHdG is efficiently repaired by a DNA glycosylase specific for this lesion (
    9
    ) and its contribution to mutagenesis is relatively weak (
    10

    12
    ). However, it is representative of approximately 20 additional oxidatively-denved lesions known to result from radiation damage (
    13
    ) and whose mutagenic outcome are largely unknown in mammalian-cell systems.
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