Electron Paramagnetic Resonance Spin-Labeling Analysis of Synaptosomal Membrane Protein Oxidation
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Last Update: 2020-12-20
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Source: Internet
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Author: User
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Synaptosomal protein oxidation, most often indexed by increased protein carbonyl content (
1
,
2
), is one biomarker of oxidative stress in brain (
2
). Protein carbonyls are detected by UV-Vis spectrometric, fluorescence, or immunochemical methods (
2
), and are increased in a variety of oxidative stress disorders of the brain. Among the latter are Alzheimer’s disease (AD) (
3
) and animal models of AD (
4
), Huntington’s disease (HD) (
5
,
6
), and accelerated aging (
7
).
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