Eleven new siRNA can inhibit influenza A virus on NS, PA and NP genes

Tomsk University of science and technology of Russia and smorojinzev Influenza Research Institute of the Ministry of health of Russia have jointly developed 11 new siRNA (small interfering RNA), which have antiviral activity in vitro and can inhibit influenza A virus on NS, PA and NP genes The researchers selected the three most potent siRNAs: pa-1630, np-717, and ns-777 Their combination is a new type of anti influenza A virus complex The researchers said that the three siRNAs targeting virus genes could be encapsulated in hybrid polymer electrolyte microcapsules for the development of drugs to prevent and treat virus infection (http://www.chemdrug.com/) The researchers compared the inhibition of influenza virus in vitro by microcapsules containing these three kinds of siRNA complexes The results showed that the three kinds of encapsulated siRNA complexes had a good inhibitory effect on H1N1, H5N2 and h7n9 influenza A virus Alexandre kimin, a researcher at the Institute of chemical biomedical technology of Tomsk University of technology, said that through experimental comparison, the results showed that siRNA can be located and effectively retained in the capsule, and the microcapsule can effectively protect siRNA from degradation, which is essential for the transmission of siRNA in cells If necessary, higher biocompatibility can be achieved by surface modification.