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Interpersonal relationships need to be maintained by effective communication, as is the human microenvironment.
Recently, a research team led by the University of Sydney Research in Australia has identified a communication pathway to control cell growth and survival, which may provide new ideas for the development of treatments for diseases such as cancer and diabetes
Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis eLife eLife
Cellular communication refers to the transmission of information from one cell to another cell to produce a corresponding response through the medium
Obviously, human cells communicate mainly through the first method
As we all know, insulin as an effective growth signal, its secretion will increase after the human body eats, and promote the production of blood sugar in muscle and fat cells
PI3K/AKT signal pathway
PI3K/AKT signal pathway PI3K/AKT signal pathwayBecause the PI3K/AKT signaling pathway is closely related to insulin resistance, it is essential for the survival of eukaryotic cells
In order to solve this problem, researchers began to look for a mechanism that can control the stable conduction of this signal
Mechanism model of terminal insulin signaling
Mechanism model of end insulin signal transduction Mechanism model of end insulin signal transductionThis mechanism is centered on the main component "Akt" of the phosphoinositide 3-kinase (PI3K) signaling pathway, acting as a "failure safety" to avoid signal instability, similar to a heater or a thermostat in an oven.
Negative feedback regulation depends on Akt
Negative feedback regulation depends on Akt Negative feedback regulation depends on AktOne of the corresponding authors of the study, Dr.
In the future, it is expected that scientific researchers can further explore the mechanism of this cell communication pathway and cancer drug resistance, apply it to cancer treatment, and optimize cancer treatment strategies
Original source:
Original source:Alison L Kearney et al.
Akt phosphorylates insulin receptor substrate to limit PI3K -mediated PIP3 synthesis
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