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    Home > Biochemistry News > Biotechnology News > eLife: Gene variants associated with mobility changes during aging

    eLife: Gene variants associated with mobility changes during aging

    • Last Update: 2022-05-13
    • Source: Internet
    • Author: User
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    The findings help address why some people remain active as they age, while others find it more difficult to travel
    .
    The genetic variants identified in the study can be further evaluated to identify specific mechanisms by which individuals lose mobility over time and help predict these loss of abilities with age

    .

    Many people experience gradual loss of muscle and strength as they age, which can reduce their quality of life and lead to falls and fractures later in life
    .
    Lack of exercise or poor diet can lead to age-related muscle loss, but genetic factors may also play a role

    .

    "While aging is a universal phenomenon, the genetic factors that contribute to individual differences as we age are unknown
    .
    We wanted to study the role that genetic variations in mitochondrial enzymes play in age-related changes in mobility," said U.
    S.
    South Osvaldo Villa, a doctoral student at the UC Leonard Davis School of Geriatrics, explained

    .
    Vera co-authored the study with doctoral students Nicole Stewart and Dr.
    Yan Jiaan

    .

    In their study, the team screened the roundworm C.
    elegans for genetic variants that lead to the accumulation of oxidative stress, a process that can lead to cell damage in muscle tissue

    .
    They found that a variant of a gene called ALH-6 is associated with oxidative stress

    .
    Over time, these mutated worms became less able to crawl and swim

    .

    Next, the team analyzed data from the U.
    S.
    Health and Retirement Study (HRS) to see if the genetic equivalent of the ALDH4A1 gene variant in humans was also associated with age-related changes in mobility

    .
    HRS recruited more than 36,000 U.
    S.
    adults age 50 and older and collected genetic and health information

    .
    By analyzing the participants' genetic data and strength measurements, the researchers found that older adults with specific ALDH4A1 gene variants walked slower and had less hand strength as they got older

    .

    "These findings suggest that variants in the ALH-6 or ALDH4A1 genes can affect muscle aging in C.
    elegans and in humans, and may help predict muscle fitness in people as they age," Stuhr said

    .

    The team warns that many human genes may interact with age, along with diet and other factors, to influence strength and mobility
    .
    More research is needed to understand all the genes involved in these age-related changes

    .

    "Because of the limited amount of data on human aging, biomarkers predicting muscle strength and flexibility are extremely rare," concludes senior author Sean Curran, gerontology, molecular and computational biology at the USC Leonard Davis School of Geriatrics.
    Professor of Science, Associate Dean for Research

    .
    "Drs Arpawong's expertise and crimmin cross-species genome translation hit the USC-Buck Nathan Centre of Excellence in the core biology of basic biology of aging, and we now plan to collaborate with other researchers to allow them to integrate genetic research models with human gene-wide association scanning methods

    .
    Building on our work could help identify new predictors of muscle health and other age-related disorders

    .
    "

    Journal Reference :

    1. Osvaldo Villa, Nicole L Stuhr, Chia-an Yen, Eileen M Crimmins, Thalida Em Arpawong, Sean P Curran.
      Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species .
      eLife , 2022; 11 DOI: 10.
      7554/eLife .
      74308


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